ArticleJournal of economic entomology2023
Insights into the toxicity, biochemical activity, and molecular docking of Cymbopogon citratus essential oils and citral on Spodoptera littoralis (Lepidoptera: Noctuidae).
Article in Journal of economic entomology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Enhanced polyphenolic production in tissue culture-derived Opuntia ficus-indica increases larvicidal activity against Spodoptera exigua: biochemical, histological and molecular docking evidence.Scientific reports · 2026Article
- Comparative insecticidal efficacy and biochemical impact of nano-encapsulated citronella and geranium essential oils against Spodoptera littoralis (Lepidoptera: Noctuidae).Scientific reports · 2026Article
- In Silico Analysis of Two Hard Tick P450s: Identification, Characterization, and Putative Metabolism ofInternational journal of molecular sciences · 2025Article
- Insecticidal effects of nano-encapsulated lemongrass essential oil on the population parameters of Spodoptera frugiperda using two-sex life table.Scientific reports · 2025Article
- Utilizing ADMET Analysis and Molecular Docking to Elucidate the Neuroprotective Mechanisms of a Cannabis-Containing Herbal Remedy (Suk-Saiyasna) in Inhibiting Acetylcholinesterase.International journal of molecular sciences · 2025Article
- Article
- Differential detoxification enzyme profiles in C-corn strain and R-rice strain of Spodoptera frugiperda by comparative genomic analysis: insights into host adaptation.BMC genomics · 2025Article
- Biological Characteristics of the Cytochrome P 450 Family and the Mechanism of Terpinolene Metabolism inInternational journal of molecular sciences · 2024Article
- Monitoring and Detection of Insecticide Resistance inInsects · 2024Article
- Target Enzymes ofInsects · 2024Article
- Lethal and Sublethal Effects of Cyantraniliprole on the Biology and Metabolic Enzyme Activities of Two Lepidopteran Pests,Insects · 2024Article
- Antiviral, Antibacterial, Antifungal, and Anticancer Activity of Plant Materials Derived fromPharmaceuticals (Basel, Switzerland) · 2024Review
- The Synergistic Effect of Lemongrass Essential Oil and Flometoquin, Flonicamid, and Sulfoxaflor onInsects · 2024Article
- Chemical composition of four essential oils and their adulticidal, repellence, and field oviposition deterrence activities against Culex pipiens L. (Diptera: Culicidae).Parasitology research · 2024Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Insecticide resistance is a significant problem in insect management that can result from several processes including target-site change and increased activity of detoxifying enzymes. Spodoptera littoralis is one of the most resistant insect pests. For more effective insect management, alternatives to synthetic pesticides are encouraged. One of these alternatives is essential oils (EOs). Cymbopogon citratus EO and its main constituent citral were, therefore, considered in this study. The results revealed that C. citratus EO and citral exhibited significant larvicidal activity against S. littoralis, and the former was insignificantly more toxic than the latter. Additionally, treatments significantly affected the activity of detoxification enzymes. Cytochrome P-450 and glutathione-S-transferase were inhibited, while carboxylesterases, a-esterase and β-esterase, were induced. The molecular docking study indicated that citral bonded with the amino acids cysteine (CYS 345) and histidine (HIS 343) of cytochrome P-450. This result suggests that interaction with cytochrome P-450 enzyme is one key mechanism by which C. citratus EO and citral act in S. littoralis. The results of our study are hoped to contribute to a better understanding of the mechanism of action of essential oils at the biochemical and molecular levels and provide safer and more efficient pest management solutions for S. littoralis.
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