ArticleMicrobiology spectrum2023
Estragole Inhibits Growth and Aflatoxin Biosynthesis of
Article in Microbiology spectrum, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 14 citations in OpenAlex.
- A Redox-Lipid Transcriptional State Is Associated with High Aflatoxin Biosynthetic Activity inMetabolites · 2026Article
- Nanofabricated essential oils as a green antifungal agent for the management of aflatoxin BArchives of microbiology · 2026Review
- Algal extract as a key protective agent: Jania rubens-enriched PVA/CMC coatings for postharvest onion disease control.BMC plant biology · 2026Article
- Antifungal Activity of Natural Thymol: Advances on Molecular Mechanisms and Therapeutic Potential.Biomolecules · 2026Review
- Fungal Contamination of Dairy Feed and Major Mycotoxin Transfer: A Risk Evaluation for Animal Exposure and Health.Toxins · 2026Article
- Pine monoterpenes drive growth, competition, and volatile metabolism of symbiotic fungi associated with the mountain pine beetle.FEMS microbiology letters · 2026Article
- Dual defense mechanisms from a novel marine fungusFrontiers in microbiology · 2026Article
- A comprehensive insight into peanut storage: patterns of quality changes, pathways of quality deterioration, and storage strategies.Food chemistry: X · 2025Review
- Protocatechuic acid inhibits aflatoxin production and modulates gene expression in Aspergillus flavus.Scientific reports · 2025Article
- Aromatic Herbs as a Source of Bioactive Compounds: An Overview of Their Antioxidant Capacity, Antimicrobial Activity, and Major Applications.Molecules (Basel, Switzerland) · 2025Review
- Inhibition Mechanism ofFoods (Basel, Switzerland) · 2025Article
- Rhein Inhibits Cell Development and Aflatoxin Biosynthesis via Energy Supply Disruption and ROS Accumulation inToxins · 2024Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A variety of essential oils and edible compounds have been widely recognized for their antifungal activity in recent years. In this study, we explored the antifungal activity of estragole from Pimenta racemosa against Aspergillus flavus and investigated the underlying mechanism of action. The results showed that estragole had significant antifungal activity against A. flavus, with a minimum inhibitory concentration of 0.5 μL/mL against spore germination. Additionally, estragole inhibited the biosynthesis of aflatoxin in a dose-dependent manner, and aflatoxin biosynthesis was significantly inhibited at 0.125 μL/mL. Pathogenicity assays showed that estragole had potential antifungal activity against A. flavus in peanut and corn grains by inhibiting conidia and aflatoxin production. Transcriptomic analysis showed that the differentially expressed genes (DEGs) were mainly related to oxidative stress, energy metabolism, and secondary metabolite synthesis following estragole treatment. Importantly, we experimentally verified reactive oxidative species accumulation following downregulation of antioxidant enzymes, including catalase, superoxide dismutase, and peroxidase. These results suggest that estragole inhibits the growth and aflatoxin biosynthesis of A. flavus by modulating intracellular redox homeostasis. These findings expand our knowledge on the antifungal activity and molecular mechanisms of estragole, and provide a basis for estragole as a potential agent against A. flavus contamination.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.