Evidence map›Paper›PMID 37288750›Full record

ArticleEmerging microbes & infections2023

Unexpected rise in the circulation of complex HBV variants enriched of HBsAg vaccine-escape mutations in HBV genotype-D: potential impact on HBsAg detection/quantification and vaccination strategies.

Lorenzo Piermatteo, Stefano D'Anna, Ada Bertoli, Maria Bellocchi, Luca Carioti, Lavinia Fabeni, Mohammad Alkhatib, Simone La Frazia, Miriam Lichtner, Claudio Mastroianni and 14 more

Open access · goldAbstract read
In one paragraph

Article in Emerging microbes & infections, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 10 institutions in 4 countries.

Lorenzo PiermatteoDepartment of Biology, Tor Vergata University, Rome, Italy.
Stefano D'AnnaDepartment of Experimental Medicine, Tor Vergata University, Rome, Italy.
Ada BertoliDepartment of Experimental Medicine, Tor Vergata University, Rome, Italy.
Maria BellocchiDepartment of Experimental Medicine, Tor Vergata University, Rome, Italy.
Luca CariotiDepartment of Experimental Medicine, Tor Vergata University, Rome, Italy.
Lavinia FabeniNational Institute for Infectious Disease, IRCCS L. Spallanzani, Virology and Biosafety Laboratories Unit, Rome, Italy.
Mohammad AlkhatibDepartment of Experimental Medicine, Tor Vergata University, Rome, Italy.
Simone La FraziaDepartment of Biology, Tor Vergata University, Rome, Italy.
Miriam LichtnerDepartment of Public Health and Infectious Disease, "Sapienza" University, Rome, Italy.
Claudio MastroianniDepartment of Public Health and Infectious Disease, "Sapienza" University, Rome, Italy.
Giuseppe De Sanctis"Umberto I" University Hospital, Rome, Italy.
Massimo MarignaniDepartment of Gastroenterology, "S. Andrea Hospital", Rome, Italy.
Caterina PasquazziDepartment of Gastroenterology, "S. Andrea Hospital", Rome, Italy.
Nerio Iapadre"San Salvatore Hospital", L'Aquila, Italy.
Giustino ParrutiInfectious Diseases Unit, Pescara General Hospital, Pescara, Italy.
Giuseppina CappielloMicrobiology and Virology Unit, "S. Pertini" Hospital, Rome, Italy.
Jacopo VecchietClinic of Infectious Diseases, Department of Medicine and Science of Aging, University "G. d'Annunzio" Chieti-Pescara, Chieti, Italy.
Vincenzo MalagninoInfectious Diseases Unit, Tor Vergata University Hospital, Rome, Italy.
Sandro GrelliDepartment of Experimental Medicine, Tor Vergata University, Rome, Italy.
Francesca Ceccherini-SilberteinDepartment of Experimental Medicine, Tor Vergata University, Rome, Italy.
Massimo AndreoniInfectious Diseases Unit, Tor Vergata University Hospital, Rome, Italy.
Loredana SarmatiInfectious Diseases Unit, Tor Vergata University Hospital, Rome, Italy.
Valentina SvicherDepartment of Biology, Tor Vergata University, Rome, Italy.
Romina SalpiniDepartment of Biology, Tor Vergata University, Rome, Italy.
University of Rome Tor Vergata · ITSapienza University of Rome · ITAzienda USL di Pescara · ITCenter for Prevention and Treatment of Infections · USCTO Andrea Alesini · ITInstitute of Virology of the Slovak Academy of Sciences · SKOspedali Riuniti Umberto I · ITSan Salvatore Hospital · ITSt Andrew’s Hospital · AUUniversity of Chieti-Pescara · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Specific HBsAg mutations are known to hamper HBsAg recognition by neutralizing antibodies thus challenging HBV-vaccination efficacy. Nevertheless, information on their impact and spreading over time is limited. Here, we characterize the circulation of vaccine-escape mutations from 2005 to 2019 and their correlation with virological parameters in a large cohort of patients infected with HBV genotype-D (

Indexed as

Hepatitis B Surface AntigensHepatitis B virusDNA, ViralGenotypeHepatitis B VaccinesHumansMutationVaccinationDNA, ViralHepatitis B Surface AntigensHepatitis B VaccinesHBsAgHBsAg antigenicityHBsAg secretionHBVvaccine-escape mutations

Identifiers

PMID37288750
PMCPMC10251786
OpenAlexW4379768645

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.