Evidence map›Paper›PMID 37288612›Full record

Trial reportJPEN. Journal of parenteral and enteral nutrition2023

Association between parenteral nutrition-containing intravenous lipid emulsion and bloodstream infections in patients with single-lumen central venous access: A secondary analysis of a randomized trial.

Nicole C Gavin, Emily Larsen, Naomi Runnegar, Gabor Mihala, Samantha Keogh, David McMillan, Gillian Ray-Barruel, Claire M Rickard

Open access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in JPEN. Journal of parenteral and enteral nutrition, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Trial
  2. Observational
  3. Observational
  4. Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Nicole C GavinCancer Care Services, Royal Brisbane and Women's Hospital, Queensland, Australia.ORCID 0000-0002-0828-9852
Emily LarsenAlliance for Vascular Access Teaching and Research Group, School of Nursing and Midwifery, Griffith University, Queensland, Australia.
Naomi RunnegarFaculty of Medicine, University of Queensland, Queensland, Australia.
Gabor MihalaAlliance for Vascular Access Teaching and Research Group, School of Nursing and Midwifery, Griffith University, Queensland, Australia.
Samantha KeoghAlliance for Vascular Access Teaching and Research Group, School of Nursing and Midwifery, Griffith University, Queensland, Australia.
David McMillanAlliance for Vascular Access Teaching and Research Group, School of Nursing and Midwifery, Griffith University, Queensland, Australia.
Gillian Ray-BarruelAlliance for Vascular Access Teaching and Research Group, School of Nursing and Midwifery, Griffith University, Queensland, Australia.
Claire M RickardAlliance for Vascular Access Teaching and Research Group, School of Nursing and Midwifery, Griffith University, Queensland, Australia.
Griffith University · AUThe University of Queensland · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDistinguishing primary bloodstream infections (BSIs) related to central venous access devices (CVADs) from those that occur through other mechanisms, such as a damaged mucosal barrier, is difficult.

methodsSecondary analysis was conducted on data from patients with CVADs that were collected for a large, randomized trial. Patients were divided into two groups: those who received parenteral nutrition (PN)-containing intravenous lipid emulsion (ILE) and those who did not have PN-containing ILE. This study investigated the influence of PN-containing ILE (ILE PN) on primary BSIs in patients with a CVAD.

resultsOf the 807 patients, 180 (22%) received ILE PN. Most (627/807; 73%) were recruited from the hematology and hematopoietic stem cell transplant unit, followed by surgical (90/807; 11%), trauma and burns (61/807; 8%), medical (44/807; 5%), and oncology (23/807; 3%). When primary BSI was differentiated as a central line-associated BSI (CLABSI) or mucosal barrier injury laboratory-confirmed BSI (MBI-LCBI), the incidence of CLABSI was similar in the ILE PN and non-ILE PN groups (15/180 [8%] vs 57/627 [9%]; P = 0.88) and the incidence of MBI-LCBI was significantly different between groups (31/180 [17%] ILE PN vs 41/627 [7%] non-ILE PN; P < 0.01).

conclusionOur data indicate that twice as many primary BSIs in ILE PN patients are due to MBIs than CVADs. It is important to consider the MBI-LCBI classification, as some CLABSI prevention efforts aimed at CVADs for the ILE PN population may be better directed to gastrointestinal tract protection interventions.

Indexed as

Catheterization, Central VenousCatheter-Related InfectionsCentral Venous CathetersSepsisFat Emulsions, IntravenousHumansMucous MembraneParenteral NutritionRetrospective StudiesFat Emulsions, Intravenousadministration, intravenouscatheterization, central venouscatheter-related infectionscentral venous cathetersclinical nursing researchfat emulsion, intravenousmucosal barrier injury laboratory-confirmed bloodstream infectionparenteral nutritionvascular access devices

Identifiers

PMID37288612
PMCPMC10946626
OpenAlexW4379768136

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.