Evidence map›Paper›PMID 37288553›Full record

Trial reportCirculation. Cardiovascular imaging2023

Left Atrial Function Predicts Atrial Arrhythmia Recurrence Following Ablation of Long-Standing Persistent Atrial Fibrillation.

Habib Rehman Khan, Haci Yakup Yakupoglu, Ines Kralj-Hans, Shouvik Haldar, Toufan Bahrami, Jonathan Clague, Anthony De Souza, Wajid Hussain, Julian Jarman, David Gareth Jones and 6 more

Registry-linked trialAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Circulation. Cardiovascular imaging, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02755688 (Catheter Ablation Versus Thoracoscopic Surgical Ablation in Long Standing Persistent Atrial Fibrillation), which is not on this map. Cited by 60 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02755688 naunknown statusnot on this map

Catheter Ablation Versus Thoracoscopic Surgical Ablation in Long Standing Persistent Atrial Fibrillation (CASA-AF)

TypeinterventionalSponsorRoyal Brompton & Harefield NHS Foundation TrustRan2015 to 2020Enrolled120ConditionsPersistent Atrial FibrillationArmsThoracoscopic Surgical ablation, Catheter ablation
3 · Its place in the literature

Who cites it

60 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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  9. Discontinuation of Oral Anticoagulation After Successful Atrial Fibrillation Ablation - Are We Ready to Change Clinical Practice in 2026?Medical science monitor : international medical journal of experimental and clinical research · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Habib Rehman KhanLondon Health Sciences Centre, University of Western Ontario, London, Canada (H.R.K.).ORCID 0000-0002-4828-5768
Haci Yakup YakupogluCardiology Department, Royal Brompton and Harefield Hospitals, Guy's and St Thomas' NHS Trust, London, United Kingdom (H.Y.Y., I.K.-H., S.H., T.B., J.C., A.D.S., W.H., J.J., D.G.J., T.S., V.M., R.K.).
Ines Kralj-HansCardiology Department, Royal Brompton and Harefield Hospitals, Guy's and St Thomas' NHS Trust, London, United Kingdom (H.Y.Y., I.K.-H., S.H., T.B., J.C., A.D.S., W.H., J.J., D.G.J., T.S., V.M., R.K.).ORCID 0000-0001-7401-6281
Shouvik HaldarCardiology Department, Royal Brompton and Harefield Hospitals, Guy's and St Thomas' NHS Trust, London, United Kingdom (H.Y.Y., I.K.-H., S.H., T.B., J.C., A.D.S., W.H., J.J., D.G.J., T.S., V.M., R.K.).ORCID 0000-0001-8129-8520
Toufan BahramiCardiology Department, Royal Brompton and Harefield Hospitals, Guy's and St Thomas' NHS Trust, London, United Kingdom (H.Y.Y., I.K.-H., S.H., T.B., J.C., A.D.S., W.H., J.J., D.G.J., T.S., V.M., R.K.).
Jonathan ClagueCardiology Department, Royal Brompton and Harefield Hospitals, Guy's and St Thomas' NHS Trust, London, United Kingdom (H.Y.Y., I.K.-H., S.H., T.B., J.C., A.D.S., W.H., J.J., D.G.J., T.S., V.M., R.K.).ORCID 0009-0002-7011-7709
Anthony De SouzaCardiology Department, Royal Brompton and Harefield Hospitals, Guy's and St Thomas' NHS Trust, London, United Kingdom (H.Y.Y., I.K.-H., S.H., T.B., J.C., A.D.S., W.H., J.J., D.G.J., T.S., V.M., R.K.).
Wajid HussainCardiology Department, Royal Brompton and Harefield Hospitals, Guy's and St Thomas' NHS Trust, London, United Kingdom (H.Y.Y., I.K.-H., S.H., T.B., J.C., A.D.S., W.H., J.J., D.G.J., T.S., V.M., R.K.).
Julian JarmanCardiology Department, Royal Brompton and Harefield Hospitals, Guy's and St Thomas' NHS Trust, London, United Kingdom (H.Y.Y., I.K.-H., S.H., T.B., J.C., A.D.S., W.H., J.J., D.G.J., T.S., V.M., R.K.).
David Gareth JonesCardiology Department, Royal Brompton and Harefield Hospitals, Guy's and St Thomas' NHS Trust, London, United Kingdom (H.Y.Y., I.K.-H., S.H., T.B., J.C., A.D.S., W.H., J.J., D.G.J., T.S., V.M., R.K.).
Tushar SalukheCardiology Department, Royal Brompton and Harefield Hospitals, Guy's and St Thomas' NHS Trust, London, United Kingdom (H.Y.Y., I.K.-H., S.H., T.B., J.C., A.D.S., W.H., J.J., D.G.J., T.S., V.M., R.K.).
Vias MarkidesCardiology Department, Royal Brompton and Harefield Hospitals, Guy's and St Thomas' NHS Trust, London, United Kingdom (H.Y.Y., I.K.-H., S.H., T.B., J.C., A.D.S., W.H., J.J., D.G.J., T.S., V.M., R.K.).
Dhiraj GuptaLiverpool Heart and Chest Hospital, United Kingdom (D.G.).ORCID 0000-0002-3490-090X
Rajdeep Khattar *Cardiology Department, Royal Brompton and Harefield Hospitals, Guy's and St Thomas' NHS Trust, London, United Kingdom (H.Y.Y., I.K.-H., S.H., T.B., J.C., A.D.S., W.H., J.J., D.G.J., T.S., V.M., R.K.).ORCID 0000-0001-5992-2315
Tom Wong *Cardiology Department, Royal Brompton and Harefield Hospitals, Guy's and St Thomas' NHS Trust, London, United Kingdom (H.Y.Y., I.K.-H., S.H., T.B., J.C., A.D.S., W.H., J.J., D.G.J., T.S., V.M., R.K.).ORCID 0000-0002-6484-4961
CASA AF Investigators

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLeft atrial (LA) function following catheter or surgical ablation of de-novo long-standing persistent atrial fibrillation (AF) and its impact on AF recurrence was studied in patients participating in the CASA-AF trial (Catheter Ablation vs. Thoracoscopic Surgical Ablation in Long Standing Persistent Atrial Fibrillation).

methodsAll patients underwent echocardiography preablation, 3 and 12 months post-ablation. LA structure and function were assessed by 2-dimensional volume and speckle tracking strain measurements of LA reservoir, conduit, and contractile strain. Left ventricular diastolic function was measured using transmitral Doppler filling velocities and myocardial tissue Doppler velocities to derive the e', E/e', and E/A ratios. Continuous rhythm monitoring was achieved using an implantable loop recorder.

resultsEighty-three patients had echocardiographic data suitable for analysis. Their mean age was 63.6±9.7 years, 73.5% were male, had AF for 22.8±11.6 months, and had a mean LA maximum volume of 48.8±13.8 mL/m

conclusionsFollowing ablation for long-standing persistent AF, improvement in LA function was greater in those who maintained sinus rhythm. LA contractile strain at 3 months was the most important determinant of AF recurrence following ablation. REGISTRATION: URL: https://www. CLINICALTRIALS: gov; Unique identifier: NCT02755688.

Indexed as

Atrial FibrillationCatheter AblationAgedAtrial Function, LeftEchocardiographyFemaleHeart AtriaHumansMaleMiddle AgedRecurrenceTreatment Outcomeablationatrial fibrillationleft atrial functionleft atrial strainsinus rhythm

Identifiers

PMID37288553
PMCPMC10281195

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.