Evidence map›Paper›PMID 37288149›Full record

ArticleBiophysics reports2021

Anti-oxidative effect of zinc in human umbilical cord mesenchymal stem cells.

Xiaodan Lu, Yifan Lin, Xiuying Lin, Qiang Zhang, Zihang Wang, Xuguang Mi, Ruobing Wang, Xiaofang Zhang, Xu Luan, Yan Liu and 3 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biophysics reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 63% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Xiaodan LuDiagnostic Medical Center, Jilin Province People's Hospital, Changchun 130021, China.
Yifan LinDiagnostic Medical Center, Jilin Province People's Hospital, Changchun 130021, China.
Xiuying LinDiagnostic Medical Center, Jilin Province People's Hospital, Changchun 130021, China.
Qiang ZhangDepartment of Clinical Laboratory, the Second Hospital of Jilin University, Changchun 130041, China.
Zihang WangGeneral Surgery, the First Hospital of Jilin University, Changchun 130021, China.
Xuguang MiDiagnostic Medical Center, Jilin Province People's Hospital, Changchun 130021, China.
Ruobing WangGeneral Surgery, the First Hospital of Jilin University, Changchun 130021, China.
Xiaofang ZhangDiagnostic Medical Center, Jilin Province People's Hospital, Changchun 130021, China.
Xu LuanDiagnostic Medical Center, Jilin Province People's Hospital, Changchun 130021, China.
Yan LiuDiagnostic Medical Center, Jilin Province People's Hospital, Changchun 130021, China.
Bing LiDepartment of Clinical Laboratory, the Second Hospital of Jilin University, Changchun 130041, China.
Yan TanDiagnostic Medical Center, Jilin Province People's Hospital, Changchun 130021, China.
Yanqiu FangDiagnostic Medical Center, Jilin Province People's Hospital, Changchun 130021, China.
People 's Hospital of Jilin Province · CNJilin University · CNSecond Affiliated Hospital of Jilin University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human umbilical cord mesenchymal stem cells (HUC-MSCs) are pluripotent and functional in many biological processes, by which releasing secretary factors to promote the self-repairing of damaged tissue or developing into functional cell at local organ. However, there is a high risk that oxidative stress would reduce the pluripotency and factor-secretion during the preparation and transplantation. Therefore, reducing oxidative stress is expected to improve the efficacy of HUC-MSCs therapy. Zinc (Zn) is an essential trace element which involves in the resistance of oxidative stress. To investigate Zn-regulated signaling pathways, we have profiled the gene expression at transcriptome level in primary HUC-MSCs treated with zinc sulfate, followed with GO and KEGG gene enrichment analysis. Zn treatment improved signal pathways for mineral absorption, cell growth, and cell death. Zn deficiency was mimicked by TPEN administration, which suppressed cell proliferation and reduced the expression of HUC-MSCs surface stem cell markers CD73, CD90 and CD105 by flow cytometry. Nuclear factor erythrocyte 2 related factor 2 (Nrf2) plays an important role in antioxidant biological processes.

Indexed as

Human umbilical cord mesenchymal stem cellsNuclear factor erythroid-2-related factor 2Oxidative stressSirtuin 3Zinc

Identifiers

PMID37288149
PMCPMC10235909
OpenAlexW3161976536

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.