Evidence map›Paper›PMID 37288090›Full record

ArticleACS catalysis2023

Highly Enantioselective Catalytic Alkynylation of Quinolones: Substrate Scope, Mechanistic Studies, and Applications in the Syntheses of Chiral

Yong Guan, Tadas A Buivydas, Remy F Lalisse, Kalen B Laybourn, Charlotte Stern, Margaret Richins, Sean M Burns, Arielle Shelby, Christopher M Hadad, Anita E Mattson

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS catalysis, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.0field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 7 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Yong GuanDepartment of Chemistry and Biochemistry, Worcester Polytechnic Institute, 60 Prescott Street, Worcester, Massachusetts 01609, United States.
Tadas A BuivydasDepartment of Chemistry and Biochemistry, Worcester Polytechnic Institute, 60 Prescott Street, Worcester, Massachusetts 01609, United States.
Remy F LalisseDepartment of Chemistry and Biochemistry, The Ohio State University, Columbus, Ohio 43210, United States.
Kalen B LaybournDepartment of Chemistry and Biochemistry, Worcester Polytechnic Institute, 60 Prescott Street, Worcester, Massachusetts 01609, United States.
Charlotte SternIntegrated Molecular Structure Education and Research Center, Northwestern University, Evanston, Illinois 60208, United States.ORCID https://orcid.org/0000-0002-9491-289X
Margaret RichinsDepartment of Chemistry and Biochemistry, Worcester Polytechnic Institute, 60 Prescott Street, Worcester, Massachusetts 01609, United States.
Sean M BurnsDepartment of Chemistry and Biochemistry, Worcester Polytechnic Institute, 60 Prescott Street, Worcester, Massachusetts 01609, United States.
Arielle ShelbyDepartment of Chemistry, Emory University, Atlanta, Georgia 30322, United States.
Christopher M HadadDepartment of Chemistry and Biochemistry, The Ohio State University, Columbus, Ohio 43210, United States.
Anita E MattsonDepartment of Chemistry and Biochemistry, Worcester Polytechnic Institute, 60 Prescott Street, Worcester, Massachusetts 01609, United States.ORCID https://orcid.org/0000-0003-4662-3468
Worcester Polytechnic Institute · USThe Ohio State University · USEmory University · USNorthwestern University · US

Funding

Silanediol Enabled Drug DiscoveryR35GM124804 · NIGMS · WORCESTER POLYTECHNIC INSTITUTE · PI MATTSON, ANITA E · 2017 to 2021
$2.0M
NIGMS NIH HHS R35 GM124804
6 · The paper itself

Abstract

The alkynylation of 4-siloxyquinolinium triflates has been achieved under the influence of copper bis(oxazoline) catalysis. The identification of the optimal bis(oxazoline) ligand was informed through a computational approach that enabled the dihydroquinoline products to be produced with up to 96% enantiomeric excess. The conversions of the dihydroquinoline products to biologically relevant and diverse targets are reported.

Identifiers

PMID37288090
PMCPMC10243307
OpenAlexW4377824958

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.