Evidence map›Paper›PMID 37288080›Full record

ArticleJAC-antimicrobial resistance2023

Evolving landscape of carbapenem-resistant

Aki Sakurai, An Q Dinh, Blake M Hanson, William C Shropshire, Samie A Rizvi, Kirsten Rydell, Truc T Tran, Audrey Wanger, Cesar A Arias, William R Miller

Open access · goldAbstract read
In one paragraph

Article in JAC-antimicrobial resistance, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. R pyocin sensitivity ofJournal of medical microbiology · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. High-riskHeliyon · 2025
    Article
  10. Study on resistance mechanisms and molecular epidemiology of carbapenem-resistantFrontiers in cellular and infection microbiology · 2025
    Article
  11. Article
  12. Article
  13. Article
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Aki SakuraiDepartment of Infectious Diseases and Microbiology, Fujita Health University School of Medicine, Toyoake, Aichi, Japan.
An Q DinhDepartment of Internal Medicine, Division of Infectious Diseases, Houston Methodist Hospital, 6560 Fannin St, Scurlock Tower, Suite 1540, Houston, TX, USA.
Blake M HansonCenter for Infectious Diseases, University of Texas Health Science Center, School of Public Health, Houston, TX, USA.ORCID https://orcid.org/0000-0003-2949-7818
William C ShropshireDepartment of Infectious Diseases, Infection Control, and Employee Health, University of Texas M. D. Anderson Cancer Center, Houston, TX, USA.ORCID https://orcid.org/0000-0001-8556-3248
Samie A RizviDepartment of Internal Medicine, Division of Infectious Diseases, Houston Methodist Hospital, 6560 Fannin St, Scurlock Tower, Suite 1540, Houston, TX, USA.
Kirsten RydellDepartment of Internal Medicine, Division of Infectious Diseases, Houston Methodist Hospital, 6560 Fannin St, Scurlock Tower, Suite 1540, Houston, TX, USA.
Truc T TranDepartment of Internal Medicine, Division of Infectious Diseases, Houston Methodist Hospital, 6560 Fannin St, Scurlock Tower, Suite 1540, Houston, TX, USA.
Audrey WangerDepartment of Pathology and Laboratory Medicine, University of Texas Health Science Center, McGovern School of Medicine, Houston, TX, USA.
Cesar A AriasDepartment of Internal Medicine, Division of Infectious Diseases, Houston Methodist Hospital, 6560 Fannin St, Scurlock Tower, Suite 1540, Houston, TX, USA.
William R MillerDepartment of Internal Medicine, Division of Infectious Diseases, Houston Methodist Hospital, 6560 Fannin St, Scurlock Tower, Suite 1540, Houston, TX, USA.ORCID https://orcid.org/0000-0002-1518-2973
Houston Methodist · USThe University of Texas Health Science Center at Houston · USFujita Health University · JPThe University of Texas MD Anderson Cancer Center · US

Funding

Project 3: Functional Microbiome and Host Signatures in Transition from Commensal to pathogenP01AI152999 · NIAID · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI ARIAS, CESAR AUGUSTO · 2020 to 2025
$12.0M
VENOUS: A translational study of enterococcal bacteremiaR01AI148342 · NIAID · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI ARIAS, CESAR AUGUSTO · 2020 to 2024
$3.9M
The LiaFSR system and antimicrobial peptide resistance in enterococciR01AI134637 · NIAID · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI Cesar Augusto Arias · 2018 to 2026
$3.7M
POR Program on Genomic Prediction of Antimicrobial Resistance in VREK24AI121296 · NIAID · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI ARIAS, CESAR AUGUSTO · 2016 to 2025
$1.5M
Texas Medical Center Training Program in Antimicrobial ResistanceT32AI141349 · NIAID · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI GARSIN, DANIELLE A · 2019 to 2023
$1.3M
Role of YxdJK and DAK in the Enterococcal Envelope Stress ResponseK08AI135093 · NIAID · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI MILLER, WILLIAM R · 2018 to 2022
$929k
Mobile Genetic Elements and Clinical Outcomes in Staphylococcus aureus BacteremiaK01AI148593 · NIAID · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI HANSON, BLAKE M · 2020 to 2023
$519k
NIAID NIH HHS K01 AI148593NIAID NIH HHS K08 AI135093NIAID NIH HHS K24 AI121296NIAID NIH HHS P01 AI152999NIAID NIH HHS R01 AI134637NIAID NIH HHS R01 AI148342NIAID NIH HHS T32 AI141349
6 · The paper itself

Abstract

Objectives: The increased identification of carbapenem-resistant Methods: A total of 169 CR-PA isolated from clinical specimens at a single centre in Houston, TX, USA were studied. Among them, 61 isolates collected between 1999 and 2005 were defined as historical strains, and 108 collected between 2017 and 2018 were defined as contemporary strains. Antimicrobial susceptibilities against selected β-lactams was determined. WGS data were used for the identification of antimicrobial resistance determinants and phylogenetic analysis. Results: Non-susceptibility to ceftolozane/tazobactam and ceftazidime/avibactam increased from 2% (1/59) to 17% (18/108) and from 7% (4/59) to 17% (18/108) from the historical to the contemporary collection, respectively. Carbapenemase genes, which were not identified in the historical collection, were harboured by 4.6% (5/108) of the contemporary strains, and the prevalence of ESBL genes also increased from 3.3% (2/61) to 16% (17/108). Genes encoding acquired β-lactamases were largely confined to the high-risk clones. Among ceftolozane/tazobactam-resistant isolates, non-susceptibility to ceftazidime/avibactam, imipenem/relebactam and cefiderocol was observed in 94% (15/16), 56% (9/16) and 12.5% (2/16), respectively. Resistance to ceftolozane/tazobactam and imipenem/relebactam was primarily associated with the presence of exogenous β-lactamases. Conclusions: Acquisition of exogenous carbapenemases and ESBLs may be a worrisome trend in

Identifiers

PMID37288080
PMCPMC10243771
OpenAlexW4379768675

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.