ReviewStructural heart : the journal of the Heart Team2022
Left Ventricular Systolic Dysfunction in Aortic Stenosis: Pathophysiology, Diagnosis, Management, and Future Directions.
Review in Structural heart : the journal of the Heart Team, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 23 citations in OpenAlex.
- Serial Changes in Left Ventricular Ejection Fraction After Transcatheter Aortic Valve Implantation: Associations With Ischemic Heart Disease and Left Ventricular End-Diastolic Diameter.Echocardiography (Mount Kisco, N.Y.) · 2026Article
- Prognostic Role of Left Atrial Reservoir Strain for Risk Stratification in Aortic Stenosis: A Systematic Review.Journal of clinical medicine · 2026Review
- Article
- Prognostic value of myocardial work indices measured on echocardiography in patients with aortic stenosis undergoing transcatheter aortic valve replacement: A systematic review and meta-analysis.Pakistan journal of medical sciences · 2026Article
- Adipocytes in Aortic Stenosis: Association With Clinical and Morphological Indices.Clinical anatomy (New York, N.Y.) · 2026Article
- Review
- Therapeutic Effects on Ectopic Burden and LV Ejection Fraction in a Patient With Aortic Stenosis Undergoing TAVR.JACC. Case reports · 2026Article
- Assessment of Potential Predictors of Aortic Stenosis Severity Using ECG-Gated Multidetector CT in Patients with Bicuspid and Tricuspid Aortic Valves Prior to TAVI.Journal of clinical medicine · 2026Article
- Ventricular Mechanics and Serum Biomarkers as Predictors of Aortic Valve Replacement in Severe Aortic Stenosis.Vascular health and risk management · 2026Article
- Evaluation of left atrial function in patients with severe aortic stenosis with preserved ejection fraction based on real-time three-dimensional automated left atrial quantification technique.Quantitative imaging in medicine and surgery · 2025Article
- Article
- Toronto Aortic Stenosis Quality of Life Questionnaire (TASQ): Validation in Polish Patients with Aortic Stenosis.Journal of clinical medicine · 2025Article
- Cardiac Rehabilitation in TAVI Patients: Safety and Benefits: A Narrative Review.Medicina (Kaunas, Lithuania) · 2025Review
- Advances in Pathophysiological Mechanisms of Degenerative Aortic Valve Disease.Cardiology research · 2025Review
- Review
- Cardiac rehabilitation for TAVR patients: mechanisms, current status, and future directions.Frontiers in cardiovascular medicine · 2025Review
- Predictive Value of Monocyte-To-Lymphocyte Ratio in Differentiating Heart Failure with Reduced Ejection Fraction in Patients with Severe Aortic Stenosis-A Retrospective Analysis.Journal of clinical medicine · 2024Article
- Article
- Galanin Coordinates Macrophage-Associated Fibro-Inflammatory Response and Mitochondrial Integrity in Myocardial Infarction Reperfusion Injury.International journal of molecular sciences · 2024Article
- Insights into calcific aortic valve stenosis: a comprehensive overview of the disease and advancing treatment strategies.Annals of medicine and surgery (2012) · 2024Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Degenerative calcific aortic stenosis (AS) is the most common valvular heart disease and often co-exists with left ventricular (LV) systolic dysfunction at the time of diagnosis. Impaired LV systolic function has been associated with worse outcomes in the setting of AS, even after successful aortic valve replacement (AVR). Myocyte apoptosis and myocardial fibrosis are the 2 key mechanisms responsible for the transition from the initial adaptation phase of LV hypertrophy to the phase of heart failure with reduced ejection fraction. Novel advanced imaging methods, based on echocardiography and cardiac magnetic resonance imaging, can detect LV dysfunction and remodeling at an early and reversible stage, with important implications for the optimal timing of AVR especially in patients with asymptomatic severe AS. Furthermore, the advent of transcatheter AVR as a first-line treatment for AS with excellent procedural outcomes, and evidence that even moderate AS portends worse prognosis in heart failure with reduced ejection fraction patients, has raised the question of early valve intervention in this patient population. With this review, we describe the pathophysiology and outcomes of LV systolic dysfunction in the setting of AS, present imaging predictors of LV recovery after AVR, and discuss future directions in the treatment of AS extending beyond the traditional indications defined in the current guidelines.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.