Evidence map›Paper›PMID 37287988›Full record

ArticleFrontiers in immunology2023

Exhaustion of CD8

Jonas Leonhard, Matthias Schaier, Florian Kälble, Martin Zeier, Andrea Steinborn

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Exhaustion of CD8Frontiers in immunology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Jonas LeonhardDepartment of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany.
Matthias SchaierDepartment of Nephrology, University of Heidelberg, Heidelberg, Germany.
Florian KälbleDepartment of Nephrology, University of Heidelberg, Heidelberg, Germany.
Martin ZeierDepartment of Nephrology, University of Heidelberg, Heidelberg, Germany.
Andrea SteinbornDepartment of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany.
Heidelberg University · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Immunosuppressive therapy prevents graft rejection but increases the risk of non-melanoma skin cancer (NMSC), especially in elderly kidney transplant recipients (KTR). Methods: In this study, we separately investigated the differentiation of CD8 Results: We found that both RTE Treg and Tresp differentiation Discussion: In conclusion, we provide evidence that immunosuppressive therapy inhibits differentiation of CD8

Indexed as

Kidney TransplantationSkin NeoplasmsAgedCD8-Positive T-LymphocytesCell DifferentiationHumansReceptors, CCR7T-Lymphocyte SubsetsReceptors, CCR7cancer immunityCD8+ regulatory T cellsCD8+ responder T cellsCD8+ T cell differentiationCD8+ T cell exhaustionimmunosuppressive therapykidney transplantationnon-melanoma skin cancer

Identifiers

PMID37287988
PMCPMC10242110
OpenAlexW4378084264

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.