ArticleFrontiers in medicine2023
Chromosomal abnormalities and structural defects in fetuses with increased nuchal translucency at a Chinese tertiary medical center.
Article in Frontiers in medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Association Between Increased Nuchal Translucency and Foetal CNS Abnormalities in Euploid Foetuses: Systematic Review and Meta-Analysis.Diagnostics (Basel, Switzerland) · 2026Review
- Association Between Fetal Nuchal Translucency Measurements and Pregnancy Outcomes.International journal of women's health · 2026Article
- Intelligent quality assessment of ultrasound images for fetal nuchal translucency measurement during the first trimester of pregnancy based on deep learning models.BMC pregnancy and childbirth · 2025Article
- Associations between genomic aberrations, increased nuchal translucency, and pregnancy outcomes: a comprehensive analysis of 2,272 singleton pregnancies in women under 35.Frontiers in medicine · 2024Article
- Enhancing Fetal Anomaly Detection in Ultrasonography Images: A Review of Machine Learning-Based Approaches.Biomimetics (Basel, Switzerland) · 2023Review
- Prevalence and diagnostic dilemma of chromosomal abnormalities in the Niger Delta area of Nigeria; Is prenatal diagnosis worthwhile?Nigerian medical journal : journal of the Nigeria Medical AssociationArticle
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Authors and funding
7 authors.
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Abstract
Objectives: To explore the pregnancy outcomes of fetuses with increased NT thickness. Methods: This was a retrospective study of fetuses with increased NT (≥95th centile) at 11-14 weeks of gestation between January 2020 and November 2020. Results: Among 264 fetuses with increased NT, the median of CRL and NT was 61.2 mm and 2.41 mm. Among them, 132 pregnancy women chose invasive prenatal diagnosis (43 cases of chorionic villus sampling (CVS), 89 cases of amniocentesis). Eventually, 16 cases of chromosomal abnormalities were discovered, including 6 cases (6.4%) of trisomy 21, 4 cases (3%) of trisomy 18, 1 case (0.8%) of 45, XO, 1 case (0.8%) of 47, XXY and 4 cases (3.03%) of CNV abnormalities. The major structural defects included hydrops (6.4%), cardiac defects (3%), and urinary anomalies (2.7%). The incidences of chromosomal abnormalities and structural defects in the NT < 2.5 mm group were 1.3 and 6%, while the incidences were 8.8 and 28.9% in the NT≥2.5 group. Conclusion: Increased NT was associated with high risk of chromosomal abnormalities and structural anomalies. Chromosomal abnormalities and structural defects could be detected when NT thickness was between 95th centile and 2.5 mm.
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