ArticleAlzheimer's & dementia (Amsterdam, Netherlands)
Representativeness of samples enrolled in Alzheimer's disease research centers.
Article in Alzheimer's & dementia (Amsterdam, Netherlands). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
66 citing papers in PubMed.
- The impact of learning about financial compensation on enrollment in Alzheimer's disease longitudinal research.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Trial
- Recruitment and retention in a preclinical AD trial: comparisons between academic and non-academic sites.Alzheimer's research & therapy · 2025Trial
- Speech clocks decode dementia phenotypes, social exposome, and biological aging.Science advances · 2026Article
- Association Between Menopausal Hormone Therapy and Alzheimer Disease Neuropathology.Neurology · 2026Article
- Engagement of understudied populations as community change: The South Texas ADRC model.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Cognitive factor structure of the NACC UDS-3 neuropsychological battery across ethno-racial, linguistic, and cognitive status groups.The Clinical neuropsychologist · 2026Article
- Potential biases associated with reported parental history of dementia in the Alzheimer's Disease Research Center cohorts: Implications for secondary data analyses.Journal of Alzheimer's disease : JAD · 2026Article
- Centralized Review of Alzheimer's Disease and Related Dementias Biomedical Repositories and Computational Methods.Bioengineering (Basel, Switzerland) · 2026Review
- No cognitive or psychological impact from returning research Alzheimer disease biomarkers: A delayed-start, noninferiority, randomized clinical trial.medRxiv : the preprint server for health sciences · 2026Article
- Refining the Parkinson's Disease Risk Estimator for Decline In Cognition Tool (PREDICT).Cognitive and behavioral neurology : official journal of the Society for Behavioral and Cognitive Neurology · 2026Article
- Neocortical tau burden determines the degree of cognitive impairment in individuals with Braak stage V neurofibrillary degeneration.Acta neuropathologica · 2026Article
- Elevated AD biomarkers do not explain cognitive performance in a community-recruited clinical trial cohort.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Attachment Insecurity and Well-Being in Dementia Spousal Caregivers: The Moderating Role of Marital Satisfaction.Biopsychosocial science and medicine · 2026Article
- Affective neuropsychiatric symptom metrics in the National Alzheimer's Coordinating Center dataset.Journal of Alzheimer's disease : JAD · 2026Article
- Outreach, Recruitment and Engagement Cores of NIA-designated Alzheimer's Disease Research Centers: Current strategies and future directions.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Review
- Leveraging electronic health records to examine differential clinical outcomes in people with Alzheimer's disease.Communications medicine · 2026Article
- Persistent functional impairment as an early indicator of cognitive decline and dementia in cognitively normal older adults.Journal of Alzheimer's disease : JAD · 2026Article
- Experiences of participant burden in an Alzheimer's disease research center longitudinal cohort.Journal of Alzheimer's disease : JAD · 2026Article
- Successful strategies for supporting diverse representation in Alzheimer's disease research.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Evaluation of a panel of plasma biomarkers for Alzheimer's disease in a diverse research cohort.Journal of Alzheimer's disease : JAD · 2026Article
6 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
To generalize findings on the mechanisms and prognosis in Alzheimer's disease and related dementias (ADRD), it is critical for ADRD research to be representative of the population. Sociodemographic and health characteristics across ethnoracial groups included in the National Alzheimer's Coordinating Center sample (NACC) were compared to the nationally representative Health and Retirement Study (HRS). Baseline NACC data ( NACC participants were older, more educated, with worse subjective memory and hearing, but endorsed fewer depressive symptoms compared to HRS participants. While all racial and ethnic groups in NACC differed from HRS participants in the same way overall, these differences were further amplified between racial and ethnic groups. NACC participants do not represent the U.S. population in key demographic and health factors, which differed by race and ethnicity. HIGHLIGHTS: We examined selection factors included in NACC studies compared to a nationally representative sample.Selection factors included demographic and health factors and self-reported memory concerns.Results suggest that NACC participants are not representative of the U.S. population.Importantly, selection factors differed across racial and ethnic groups.Findings are suggestive of selection bias within NACC studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.