ArticleBrain and behavior2023
Major complications associated with unfavorable outcome in right-sided large hemisphere infarctions: A single-center study.
Article in Brain and behavior, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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5 citing papers in PubMed, 8 citations in OpenAlex.
- The value of electroencephalography features in the prognostic evaluation of large hemispheric infarction patients at different time intervals.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Article
- Predictors of poor outcomes in patients with intracerebral hemorrhage.Frontiers in neurology · 2025Article
- Article
- Validation and refinement of a predictive nomogram using artificial intelligence: assessing in-hospital mortality in patients with large hemispheric cerebral infarction.Frontiers in neurology · 2024Article
- Major complications associated with unfavorable outcome in right-sided large hemisphere infarctions: A single-center study.Brain and behavior · 2023Article
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7 authors at 1 institution in 1 country.
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Abstract
objectivesTo identify the major complications independently associated with unfavorable outcomes in right-sided large hemisphere infarction (RLHI) patients.
methodsWe retrospectively enrolled consecutive patients admitted within 24 h with the diagnosis of RLHI. The unfavorable outcome was defined as a modified Rankin Scale score of 4-6 at 3 months. Univariate and multivariate analyses were performed to identify the major complications independently associated with 3-month unfavorable outcomes.
resultsOf the 171 cases with RLHI included, 126 (73.7%) had unfavorable outcomes at 3 months: A total of 64 (37.4%) cases died, and 62 (36.3%) lived with severe disability. Stroke-related complications occurred in 168 (98.2%) patients during hospitalization. The five most common stroke-related complications were pulmonary infection (75.4%), electrolyte disorder (61.4%), hypoalbuminemia (49.1%), malignant brain edema (MBE) (48.5%), and hemorrhagic transformation (48.0%). RLHI patients with unfavorable outcomes had more frequent MBE (58.7% vs. 21.4%, p < .001), pulmonary infection (86.5% vs. 42.9%, p < .001), gastrointestinal bleeding (46.8% vs. 28.6%, p = .038), electrolyte disorder (68.3% vs. 40.5%, p = .001), acute renal failure (32.5% vs. 4.8%, p < .001), and hypoalbuminemia (61.1% vs. 11.9%, p < .001) than patients with favorable outcome. Multivariate analyses suggested that only MBE (adjusted OR 4.06, 95% confidence interval [CI] 1.14-14.48, p = .031), pulmonary infection (adjusted OR 4.69, 95%CI 1.48-14.85, p = .009), and hypoalbuminemia (adjusted OR 6.58, 95%CI 1.74-24.86, p = .005) were independently associated with 3-month unfavorable outcome in patients with RLHI.
conclusionsMost of the RLHI patients have at least one stroke-related complication during hospitalization, and nearly three-quarters suffered unfavorable outcomes. Only MBE, pulmonary infection, and hypoalbuminemia are independently associated with 3-month unfavorable outcome.
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