ArticleCNS neuroscience & therapeutics2023
Retinal microvascular and structural changes in intracranial hypertension patients correlate with intracranial pressure.
Article in CNS neuroscience & therapeutics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.
- Exploring the utility of retinal optical coherence tomography as a biomarker for idiopathic intracranial hypertension: a systematic review.Journal of neurology · 2024Pooled it
- Retinal Microvascular Dysfunction Reflects Vascular and Alzheimer's-Related Pathology in Dementia With Lewy Bodies.CNS neuroscience & therapeutics · 2026Article
- Oculomics in the ICU: Retinal vessel autoregulation as a real-time biomarker for cerebral perfusion pressure.Brain & spine · 2026Article
- Retinal microvascular alterations reflect cerebral small vessel disease burden in frontotemporal dementia: a multimodal OCTA-MRI Study.Alzheimer's research & therapy · 2025Article
- Patterns of Retinal Damage and Visual Long-Term Consequences in Patients With Idiopathic Intracranial Hypertension.Neurology · 2025Article
- Microvascular Ultrasound Imaging in the Neonatal Brain: From Advanced Doppler to Super-Resolution.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2025Review
- Assessment of choriocapillary flow deficits in myopic children by optical coherence tomography angiography.Scientific reports · 2025Article
- A Novel Nomogram Integrating Retinal Microvasculature and Clinical Indicators for Individualized Prediction of Early Neurological Deterioration in Single Subcortical Infarction.CNS neuroscience & therapeutics · 2025Observational
- Decreased Choroidal Vascular Index in Idiopathic Intracranial Hypertension.Brain and behavior · 2025Observational
- Retinal thickness is indicative of visual loss in patients with occipital lobe infarction.Frontiers in neurology · 2025Article
- Intracranial pressure affects retinal venular complexity in idiopathic intracranial hypertension: a retrospective observational study.BMC neurology · 2024Observational
- Macular exudate in idiopathic intracranial hypertension affects outer retina and visual acuity.BMJ open ophthalmology · 2024Article
- Influence of Carotid Artery Stenting on the Retina and Choroid.Translational vision science & technology · 2024Article
- Retinal microvascular and structural changes in intracranial hypertension patients correlate with intracranial pressure.CNS neuroscience & therapeutics · 2023Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
aimsWe aimed to evaluate the retinal microvascular and structural changes in intracranial hypertension (IH) patients compared with an age- and sex-matched control group. We also investigated the association between clinical parameters and retinal changes in IH patients.
methodsIntracranial hypertension patients were divided into eyes with papilledema (IH-P) and eyes without papilledema (IH-WP). IH patients underwent lumbar puncture to measure intracranial pressure (ICP); visual acuity was performed using the Snellen chart. Optical coherence tomography (OCT) was used to image and measure the retinal nerve fiber layer (RNFL) and ganglion cell-inner plexiform layer (GCIPL) while OCT angiography was used to image and measure the superficial vascular complex (SVC) and deep vascular complex (DVC).
resultsIntracranial hypertension patients showed reduced microvascular densities and thinner retinal thicknesses compared with the control group (all p < 0.001). Compared with the control group, IH-P showed reduced microvascular densities and thinner retinal thicknesses (all p < 0.001). IH-P showed reduced SVC density and thinner retinal thicknesses when compared with IH-WP (p = 0.008 for SVC, p = 0.025 for RNFL, and p = 0.018 for GCIPL). ICP correlated with the microvascular densities and GCIPL thickness in IH patients (p = 0.025 for GCIPL, p = 0.004 for SVC, and p = 0.002 for DVC). A significant association of ICP with SVC (p = 0.010) and DVC (p = 0.005) densities were also found in IH-P.
conclusionsGiven the observed differences in these noninvasive retinal imaging markers, further research into their clinical utility in IH is needed.
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