Evidence map›Paper›PMID 37287321›Full record

ArticleNeuromodulation : journal of the International Neuromodulation Society2023

Specificity in Generalization Effects of Transcranial Direct Current Stimulation Over the Left Inferior Frontal Gyrus in Primary Progressive Aphasia.

Zeyi Wang, Bronte N Ficek, Kimberly T Webster, Olivia Herrmann, Constantine E Frangakis, John E Desmond, Chiadi U Onyike, Brian Caffo, Argye E Hillis, Kyrana Tsapkini

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuromodulation : journal of the International Neuromodulation Society, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02606422 (Effects of Transcranial Direct Current Stimulation), which is not on this map. Cited by 15 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 3 pooled it
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02606422 nacompletednot on this map

Effects of Transcranial Direct Current Stimulation (tDCS) in Spoken and Written Production in Primary Progressive Aphasia (PPA)

TypeinterventionalSponsorJohns Hopkins UniversityRan2013 to 2023Enrolled61ConditionsPrimary Progressive Aphasia, MCI, FTDArmsActive HD-tDCS plus Speech-Language Therapy, Sham plus Speech-Language Therapy
3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 3 syntheses or guidelines pooled it, 21 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Efficacy of Transcranial Direct Current Stimulation in Patients with Primary Progressive Aphasia: A Systematic Review and Updated Meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
    Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Zeyi WangDepartment of Biostatistics, Johns Hopkins School of Public Health, Baltimore, MD, USA.
Bronte N FicekDepartment of Neurology, Johns Hopkins Medicine, Baltimore, MD, USA.
Kimberly T WebsterDepartment of Neurology, Johns Hopkins Medicine, Baltimore, MD, USA; Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins Medicine, Baltimore, MD, USA.
Olivia HerrmannDepartment of Neurology, Johns Hopkins Medicine, Baltimore, MD, USA.
Constantine E FrangakisDepartment of Biostatistics, Johns Hopkins School of Public Health, Baltimore, MD, USA; Department of Psychiatry and Behavioral Sciences, Johns Hopkins Medicine, Baltimore, MD, USA; Department of Radiology, Johns Hopkins Medicine, Baltimore, MD, USA.
John E DesmondDepartment of Biostatistics, Johns Hopkins School of Public Health, Baltimore, MD, USA; Neuroscience Program, Johns Hopkins University, Baltimore, MD, USA.
Chiadi U OnyikeDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins Medicine, Baltimore, MD, USA.
Brian CaffoDepartment of Biostatistics, Johns Hopkins School of Public Health, Baltimore, MD, USA.
Argye E HillisDepartment of Biostatistics, Johns Hopkins School of Public Health, Baltimore, MD, USA; Department of Cognitive Science, Johns Hopkins Medicine, Baltimore, MD, USA; Department of Physical Medicine & Rehabilitation, Johns Hopkins Medicine, Baltimore, MD, USA.
Kyrana TsapkiniDepartment of Biostatistics, Johns Hopkins School of Public Health, Baltimore, MD, USA; Department of Cognitive Science, Johns Hopkins Medicine, Baltimore, MD, USA. Electronic address: tsapkini@jhmi.edu.
Johns Hopkins Medicine · USJohns Hopkins University · USJohns Hopkins Hospital · US

Funding

Research Education ComponentP30AG066507 · NIA · JOHNS HOPKINS UNIVERSITY · PI MARILYN S. ALBERT · 2020 to 2026
$29.3M
Telerehab for Aphasia (TERRA)P50DC014664 · NIDCD · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI FRIDRIKSSON, JULIUS · 2016 to 2025
$25.0M
NEUROBIOLOGY OF LANGUAGE PERCEPTION--FMRI INVESTIGATIONSR01DC003681 · NIDCD · UNIVERSITY OF CALIFORNIA-IRVINE · PI HICKOK, GREGORY · 1999 to 2015
$6.9M
Rehabilitation and Prophylaxis of Anomia in Primary Progressive AphasiaR01DC011317 · NIDCD · GEORGETOWN UNIVERSITY · PI FRIEDMAN, RHONDA B, MEYER, AARON M · 2011 to 2021
$6.4M
Effects of transcranial direct current stimulation in spoken and written production in primary progressive aphasiaR01DC014475 · NIDCD · JOHNS HOPKINS UNIVERSITY · PI TSAPKINI, KYRANA · 2015 to 2019
$4.1M
Transcranial direct current stimulation in typical and atypical Alzheimer's diseaseR01AG068881 · NIA · JOHNS HOPKINS UNIVERSITY · PI TSAPKINI, KYRANA · 2020 to 2024
$3.8M
Statistical methods for characterizing patients who highly-benefit from treatments and programs in Alzheimers, HIV, and other heterogeneous diseasesR01AI140854 · NIAID · JOHNS HOPKINS UNIVERSITY · PI FRANGAKIS, CONSTANTINE E · 2018 to 2021
$1.8M
Statistical methods to characterize patients who highly benefit across multifaceted clinical outcomes, from treatments in Alzheimers Disease and Related Dementias (ADRD)R01AG083423 · NIA · JOHNS HOPKINS UNIVERSITY · PI CONSTANTINE E FRANGAKIS · 2024 to 2026
$1.3M
NIAID NIH HHS R01 AI140854NIA NIH HHS P30 AG066507NIA NIH HHS R01 AG068881NIA NIH HHS R01 AG083423NIDCD NIH HHS P50 DC014664NIDCD NIH HHS R01 DC003681NIDCD NIH HHS R01 DC011317NIDCD NIH HHS R01 DC014475
6 · The paper itself

Abstract

objectivesGeneralization (or near-transfer) effects of an intervention to tasks not explicitly trained are the most desirable intervention outcomes. However, they are rarely reported and even more rarely explained. One hypothesis for generalization effects is that the tasks improved share the same brain function/computation with the intervention task. We tested this hypothesis in this study of transcranial direct current stimulation (tDCS) over the left inferior frontal gyrus (IFG) that is claimed to be involved in selective semantic retrieval of information from the temporal lobes. MATERIALS AND

methodsIn this study, we examined whether tDCS over the left IFG in a group of patients with primary progressive aphasia (PPA), paired with a lexical/semantic retrieval intervention (oral and written naming), may specifically improve semantic fluency, a nontrained near-transfer task that relies on selective semantic retrieval, in patients with PPA.

resultsSemantic fluency improved significantly more in the active tDCS than in the sham tDCS condition immediately after and two weeks after treatment. This improvement was marginally significant two months after treatment. We also found that the active tDCS effect was specific to tasks that require this IFG computation (selective semantic retrieval) but not to other tasks that may require different computations of the frontal lobes.

conclusionsWe provided interventional evidence that the left IFG is critical for selective semantic retrieval, and tDCS over the left IFG may have a near-transfer effect on tasks that depend on the same computation, even if they are not specifically trained. CLINICAL

trial registrationThe Clinicaltrials.gov registration number for the study is NCT02606422.

Indexed as

Aphasia, Primary ProgressiveTranscranial Direct Current StimulationHumansPrefrontal CortexSemanticsTemporal LobeInferior frontal gyrusprimary progressive aphasiasemantic retrievaltranscranial direct current stimulationverbal fluency

Identifiers

PMID37287321
PMCPMC10250817
OpenAlexW4307722511

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.