Evidence map›Paper›PMID 37287317›Full record

Observational studyActa obstetricia et gynecologica Scandinavica2023

Neonatal outcomes associated with time from a high fetal blood lactate concentration to operative delivery.

Magnus B Berge, Jørg Kessler, Branka M Yli, Anne Cathrine Staff, Nina Gunnes, Anne Flem Jacobsen

Registry-linked trialOpen access · diamondAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Acta obstetricia et gynecologica Scandinavica, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04779294 (The Oslo Stan vs Lactate Observational Study, an Observational Study Were we Compare the Clinical Performance of Two Adjunctive Methods to CTG in Intrapartum Fetal Monitoring), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04779294 completednot on this map

The Oslo Stan vs Lactate Observational Study, an Observational Study Were we Compare the Clinical Performance of Two Adjunctive Methods to CTG in Intrapartum Fetal Monitoring

TypeobservationalSponsorOslo University HospitalRan2018 to 2023Enrolled694ConditionsFetal MonitoringArmsSTAN ( St wave analysis) and fetal blood sample-lactate
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Observational
  3. Article
  4. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Magnus B BergeDivision of Gynecology and Obstetrics, Oslo University Hospital, Oslo, Norway.
Jørg KesslerDepartment of Obstetrics and Gynecology, Haukeland University Hospital, Bergen, Norway.ORCID 0000-0003-2931-2668
Branka M YliDivision of Gynecology and Obstetrics, Oslo University Hospital, Oslo, Norway.
Anne Cathrine StaffDivision of Gynecology and Obstetrics, Oslo University Hospital, Oslo, Norway.
Nina GunnesNorwegian Research Center for Women's Health, University of Oslo, Oslo, Norway.
Anne Flem JacobsenDivision of Gynecology and Obstetrics, Oslo University Hospital, Oslo, Norway.ORCID 0000-0002-8545-5156
Oslo University Hospital · NOHaukeland University Hospital · NOUniversity of Oslo · NO

Funding

Norwegian SIDS and Stillbirth Society (LUB-Landsforeningen for Uventet Barnedød) 300.000 NOK
6 · The paper itself

Abstract

introductionAdjunctive technologies to cardiotocography intend to increase the specificity of the diagnosis of fetal hypoxia. If correctly diagnosed, time to delivery could affect neonatal outcome. In the present study, we aimed to investigate the effect of time from when fetal distress is indicated by a high fetal blood sample (FBS) lactate concentration to operative delivery on the risk of adverse neonatal outcomes. MATERIAL AND

methodsWe conducted a prospective observational study. Deliveries with a singleton fetus in cephalic presentation at 36 CLINICALTRIALS: gov Identifier: NCT04779294.

resultsThe main analysis included 228 women with an operative delivery indicated by an FBS lactate concentration of 4.8 mmol/L or greater. The risk of all adverse neonatal outcomes was significantly increased for both DDI groups compared with the reference group (deliveries with an FBS lactate below 4.2 mmol/L within 60 minutes before delivery). In operative deliveries indicated by an FBS lactate concentration of 4.8 mmol/L or more, there was a significantly increased risk of a 5-minute Apgar score less than 7 if the DDI exceeded 20 minutes, compared with a DDI of 20 minutes or less (aOR 8.1, 95% CI 1.1-60.9). We found no statistically significant effect on other short-term outcomes for deliveries with DDI longer than 20 minutes, compared with those with DDI of 20 minutes or less (pH ≤7.10: aOR 2.0, 95% CI 0.5-8.4; transfer to the neonatal intensive care unit: aOR 1.1, 95% CI 0.4-3.5).

conclusionsAfter a high FBS lactate measurement, the increased risk of adverse neonatal outcome is further augmented if the DDI exceeds 20 minutes. These findings give support to current Norwegian guidelines for intervention in cases of fetal distress.

Indexed as

Fetal DistressLactic AcidCardiotocographyFemaleFetal BloodHumansHydrogen-Ion ConcentrationInfant, NewbornPregnancyPrenatal CareLactic Aciddecision-to-delivery intervalfetal blood samplefetal distressfetal monitoringlaborlactateoperative delivery

Identifiers

PMID37287317
PMCPMC10378001
OpenAlexW4379769554

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.