Evidence map›Paper›PMID 37286863›Full record

ArticleJournal of endocrinological investigation2023

Circulating miR-26b-5p and miR-451a as diagnostic biomarkers in medullary thyroid carcinoma patients.

Z M Besharat, S Trocchianesi, A Verrienti, R Ciampi, S Cantara, C Romei, C Sabato, T M R Noviello, A Po, A Citarella and 18 more

Erratum issuedOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of endocrinological investigation, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Medullary thyroid carcinoma diagnosis based on microRNA analysis: a case report.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026
    Article
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  4. The impact of STAiR18 on multiple myeloma survival rates.Journal of translational medicine · 2025
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

28 authors at 5 institutions in 2 countries.

Z M BesharatDepartment of Experimental Medicine, Sapienza University of Rome, Viale Regina Elena 324, 00161, Rome, Italy.
S TrocchianesiDepartment of Molecular Medicine, Sapienza University of Rome, 00161, Rome, Italy.
A VerrientiDepartment of Translational and Precision Medicine, Sapienza University of Rome, 00161, Rome, Italy.
R CiampiEndocrine Unit, Department of Clinical and Experimental Medicine, University of Pisa, 56126, Pisa, Italy.
S CantaraDepartment of Medical, Surgical and Neurological Sciences, University of Siena, 53100, Siena, Italy.
C RomeiEndocrine Unit, Department of Clinical and Experimental Medicine, University of Pisa, 56126, Pisa, Italy.
C SabatoDepartment of Experimental Medicine, Sapienza University of Rome, Viale Regina Elena 324, 00161, Rome, Italy.
T M R NovielloBiogem Scarl, Istituto di Ricerche Genetiche "Gaetano Salvatore", 83031, Ariano Irpino, Italy.
A PoDepartment of Molecular Medicine, Sapienza University of Rome, 00161, Rome, Italy.
A CitarellaDepartment of Experimental Medicine, Sapienza University of Rome, Viale Regina Elena 324, 00161, Rome, Italy.
F P CarusoBiogem Scarl, Istituto di Ricerche Genetiche "Gaetano Salvatore", 83031, Ariano Irpino, Italy.
I PanarielloThyroid Surgical Unit, IRCCS Fondazione G.Pascale, 80131, Naples, Italy.
F GiannoDepartment of Radiological, Oncological and Anatomo-Pathological Sciences, Sapienza University of Rome, 00161, Rome, Italy.
G CarpinoDepartment of Anatomical, Histological, Forensic Medicine and Orthopedics Sciences, Sapienza University of Rome, Rome, Italy.
E GaudioDepartment of Anatomical, Histological, Forensic Medicine and Orthopedics Sciences, Sapienza University of Rome, Rome, Italy.
M ChiacchiariniDepartment of Experimental Medicine, Sapienza University of Rome, Viale Regina Elena 324, 00161, Rome, Italy.
L MasuelliDepartment of Experimental Medicine, Sapienza University of Rome, Viale Regina Elena 324, 00161, Rome, Italy.
M SponzielloDepartment of Translational and Precision Medicine, Sapienza University of Rome, 00161, Rome, Italy.
V PecceDepartment of Translational and Precision Medicine, Sapienza University of Rome, 00161, Rome, Italy.
T RamoneEndocrine Unit, Department of Clinical and Experimental Medicine, University of Pisa, 56126, Pisa, Italy.
F MainoDepartment of Medical, Surgical and Neurological Sciences, University of Siena, 53100, Siena, Italy.
F DottaDepartment of Medical, Surgical and Neurological Sciences, University of Siena, 53100, Siena, Italy.
M CeccarelliBiogem Scarl, Istituto di Ricerche Genetiche "Gaetano Salvatore", 83031, Ariano Irpino, Italy.
L PezzulloThyroid Surgical Unit, IRCCS Fondazione G.Pascale, 80131, Naples, Italy.
C DuranteDepartment of Translational and Precision Medicine, Sapienza University of Rome, 00161, Rome, Italy. cosimo.durante@uniroma1.it.ORCID http://orcid.org/0000-0002-1791-5915
M G CastagnaDepartment of Medical, Surgical and Neurological Sciences, University of Siena, 53100, Siena, Italy.
R EliseiEndocrine Unit, Department of Clinical and Experimental Medicine, University of Pisa, 56126, Pisa, Italy.
E FerrettiDepartment of Experimental Medicine, Sapienza University of Rome, Viale Regina Elena 324, 00161, Rome, Italy. elisabetta.ferretti@uniroma1.it.ORCID http://orcid.org/0000-0001-7265-6429
Sapienza University of Rome · ITUniversity of Pisa · ITUniversity of Siena · ITBiogem · ITIstituto Nazionale Tumori IRCCS "Fondazione G. Pascale" · IT

Funding

Agenzia Italiana del Farmaco, Ministero della Salute TRS-2016-00001141Sapienza Università di Roma Sapienza Research Grant Ateneo 2018
6 · The paper itself

Abstract

PURPOSE/

methodsThe determination of tumour biomarkers is paramount to advancing personalized medicine, more so in rare tumours like medullary thyroid carcinoma (MTC), whose diagnosis is still challenging. The aim of this study was to identify non-invasive circulating biomarkers in MTC. To achieve this goal, paired MTC tissue and plasma extracellular vesicle samples were collected from multiple centres and microRNA (miRNA) expression levels were evaluated.

resultsThe samples from a discovery cohort of 23 MTC patients were analysed using miRNA arrays. Lasso logistic regression analysis resulted in the identification of a set of circulating miRNAs as diagnostic biomarkers. Among them, miR-26b-5p and miR-451a, were highly expressed and their expression decreased during follow-up in disease-free patients in the discovery cohort. Circulating miR-26b-5p and miR-451a were validated using droplet digital PCR in a second independent cohort of 12 MTC patients.

conclusionThis study allowed the identification and validation of a signature of two circulating miRNAs, miR-26b-5p and miR-451a, in two independent cohorts reporting a significant diagnostic performance for MTC. The results of this study offer advancements in molecular diagnosis of MTC proposing a novel non-invasive tool to use in precision medicine.

Indexed as

Circulating MicroRNAMicroRNAsThyroid NeoplasmsBiomarkersBiomarkers, TumorCarcinoma, NeuroendocrineHumansBiomarkersBiomarkers, TumorCirculating MicroRNAMicroRNAsDiagnostic biomarkersLiquid biopsyMedullary thyroid carcinomamiR-26b-5pmiR-451aPlasma extracellular miRNAs/circulating miRNAs

Identifiers

PMID37286863
PMCPMC10632281
OpenAlexW4379745918

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.