Evidence map›Paper›PMID 37286847›Full record

ArticleCancer causes & control : CCC2023

Associations of gut microbiome with endogenous estrogen levels in healthy postmenopausal women.

Lusine Yaghjyan, Volker Mai, Lancia N F Darville, Jayden Cline, Xuefeng Wang, Maria Ukhanova, Massimiliano S Tagliamonte, Yessica C Martinez, Shannan N Rich, John M Koomen and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer causes & control : CCC, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.2field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 citations in OpenAlex.

  1. Review
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  7. Fecal sample biobanking for breast cancer research focused on the gut microbiome.medRxiv : the preprint server for health sciences · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Lusine YaghjyanDepartment of Epidemiology, College of Public Health and Health Professions and College of Medicine, University of Florida, 2004 Mowry Rd, Gainesville, FL, 32610, USA. lyaghjyan@ufl.edu.ORCID http://orcid.org/0000-0002-1626-5340
Volker MaiDepartment of Epidemiology, College of Public Health and Health Professions and College of Medicine, University of Florida, 2004 Mowry Rd, Gainesville, FL, 32610, USA.
Lancia N F DarvilleH. Lee Moffitt Cancer Center, Tampa, FL, USA.
Jayden ClineH. Lee Moffitt Cancer Center, Tampa, FL, USA.
Xuefeng WangH. Lee Moffitt Cancer Center, Tampa, FL, USA.
Maria UkhanovaEmerging Pathogens Institute, University of Florida, Gainesville, FL, USA.
Massimiliano S TagliamonteEmerging Pathogens Institute, University of Florida, Gainesville, FL, USA.
Yessica C MartinezH. Lee Moffitt Cancer Center, Tampa, FL, USA.
Shannan N RichDepartment of Epidemiology, College of Public Health and Health Professions and College of Medicine, University of Florida, 2004 Mowry Rd, Gainesville, FL, 32610, USA.
John M KoomenH. Lee Moffitt Cancer Center, Tampa, FL, USA.
Kathleen M EganH. Lee Moffitt Cancer Center, Tampa, FL, USA.
Moffitt Cancer Center · USUniversity of Florida · US

Funding

TRANSLATIONAL RESEARCHP30CA076292 · NCI · UNIVERSITY OF SOUTH FLORIDA · PI Christine O'Connell · 1998 to 2026
$93.5M
Center for Biomedical Informatics and Information Technology, National Cancer Institute P30-CA076292NCI NIH HHS P30 CA076292
6 · The paper itself

Abstract

purposeThe gut microbiome is a potentially important contributor to endogenous estrogen levels after menopause. In healthy postmenopausal women, we examined associations of fecal microbiome composition with levels of urinary estrogens, their metabolites, and relevant metabolic pathway ratios implicated in breast cancer risk.

methodsEligible postmenopausal women (n = 164) had a body mass index (BMI) ≤ 35 kg/m

resultsIn this sample of 164 healthy postmenopausal women, the mean age was 62.9 years (range 47.0-86.0). We found significant inverse associations of observed species with 4-pathway:total estrogens (p = 0.04) and 4-pathway:2-pathway (p = 0.01). Shannon index was positively associated with 2-catechols: methylated 2-catechols (p = 0.04). Chao1 was inversely associated with E1:total estrogens (p = 0.04), and 4-pathway:2-pathway (p = 0.02) and positively associated with 2-pathway:parent estrogens (p = 0.01). Phylogenetic diversity was inversely associated with 4-pathway:total estrogens (p = 0.02), 4-pathway:parent estrogens (p = 0.03), 4-pathway:2-pathway (p = 0.01), and 4-pathway:16-pathway (p = 0.03) and positively associated with 2-pathway:parent estrogens (p = 0.01). F/B ratio was not associated with any of the estrogen measures.

conclusionMicrobial diversity was associated with several estrogen metabolism ratios implicated in breast cancer risk. Further studies are warranted to confirm these findings in a larger and more representative sample of postmenopausal women, particularly with enrichment of minority participants.

Indexed as

Breast NeoplasmsGastrointestinal MicrobiomeAgedAged, 80 and overCatecholsEstrogensFemaleHumansMiddle AgedPhylogenyPostmenopauseRNA, Ribosomal, 16SCatecholsEstrogensRNA, Ribosomal, 16SBreast cancer riskEstrogensGut microbiome

Identifiers

PMID37286847
PMCPMC12637211
OpenAlexW4379654700

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.