Evidence map›Paper›PMID 37286777›Full record

ArticleMolecular biology reports2023

SBF2-AS1 and TreRNA: novel lncRNA players in triple-negative breast cancer pathogenesis.

Zeeba Kamaliyan, Kimia Dorraji, Setare Kakavand, Ghasem Azizi-Tabesh, Nikta Mirfakhraie, Ramesh Omranipour, Nasrin Ahmadinejad, Vahid-Reza Yassaee, Reza Mirfakhraie

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Article in Molecular biology reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Zeeba KamaliyanDepartment of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Koodakyar St, Velenjak Ave, Chamran Highway, Tehran, 19395-4719, Iran.
Kimia DorrajiDepartment of Biology, Faculty of Biological Sciences, Tehran North Branch, Islamic Azad University, Tehran, Iran.
Setare KakavandDepartment of Biology, Faculty of Biological Sciences, Tehran North Branch, Islamic Azad University, Tehran, Iran.
Ghasem Azizi-TabeshDepartment of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Koodakyar St, Velenjak Ave, Chamran Highway, Tehran, 19395-4719, Iran.
Nikta MirfakhraieDepartment of computer engineering, Tehran North Branch, Islamic Azad University, Tehran, Iran.
Ramesh OmranipourBreast Disease Research Center (BDRC), Tehran University of Medical Sciences, Tehran, Iran.
Nasrin AhmadinejadMedical imaging center, Cancer Research Institute, Advanced Diagnostic and Interventional Radiology Research Center (ADIR), Tehran University of Medical Sciences, Tehran, Iran.
Vahid-Reza YassaeeDepartment of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Koodakyar St, Velenjak Ave, Chamran Highway, Tehran, 19395-4719, Iran.
Reza MirfakhraieDepartment of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Koodakyar St, Velenjak Ave, Chamran Highway, Tehran, 19395-4719, Iran. reza_mirfakhraie@yahoo.com.ORCID http://orcid.org/0000-0003-1709-8975
Shahid Beheshti University of Medical Sciences · IRIslamic Azad University North Tehran Branch · IRTehran University of Medical Sciences · IR

Funding

School of Medicine, Shahid Beheshti University of Medical Sciences 25169
6 · The paper itself

Abstract

backgroundCompared to other breast cancer subtypes, triple-negative breast cancer (TNBC) has always been challenging for clinicians due to its aggressive behavior and lack of a specific treatment. There is a confirmed association between invasive features of tumors and increased epithelial-mesenchymal transition (EMT) process, which is consistent with a higher rate of EMT in TNBC. METHODS AND

resultsWe investigated the expression of EMT-related genes, SNAI1 and MMP7, and EMT-related lncRNAs, treRNA and SBF2-AS1, in 50 TNBC tumors and 50 non-TNBC tumors to reveal more regulators and effectors involved in TNBC malignancy. In the present study, we showed the overexpression of all the studied genes and lncRNAs in TNBC tumors compared to non-TNBC samples. Moreover, a significant association was observed between MMP7 and treRNA expression levels and larger tumor size. A positive correlation between SNAI1 and lncRNA treRNA expression levels was also detected.

conclusionsDue to the differential expression and the potential diagnostic power of the studied genes, SBF2-AS1 and treRNA can be proposed as new probable biomarkers and therapeutic targets in TNBC.

Indexed as

MicroRNAsRNA, Long NoncodingTriple Negative Breast NeoplasmsCell Line, TumorCell ProliferationEpithelial-Mesenchymal TransitionGene Expression Regulation, NeoplasticHumansMatrix Metalloproteinase 7Matrix Metalloproteinase 7MicroRNAsRNA, Long NoncodingEMTMMP7SBF2-AS1SNAI1TreRNATriple-negative breast cancer

Identifiers

PMID37286777
OpenAlexW4379654671

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.