ArticleCanadian journal of anaesthesia = Journal canadien d'anesthesie2023
The Fragility Index of randomized controlled trials in pediatric anesthesiology.
Article in Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Risk factors for pediatric emergence delirium: a systematic review.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2025Pooled it
- Perioperative clinical practice recommendations for pediatric tonsillectomy: a systematic review.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2024Pooled it
- In reply: Comment on: "Dexmedetomidine in pediatric tonsillectomy: a systematic review with meta-analysis".Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2026Article
- Fragility Index and Fragility Quotient in Statistically Significant Randomized Controlled Trials in Plastic Breast Surgery.Plastic and reconstructive surgery. Global open · 2024Article
- Comment on: The fragility index of randomized controlled trials in pediatric anesthesiology.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2024Article
- In reply: Comment on: The fragility index of randomized controlled trials in pediatric anesthesiology.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2024Article
- How to mitigate confounding factors in observational studies.Journal of anesthesia · 2023Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe P value is a widely used measure of statistical importance but has many drawbacks and limitations, one being that it does not reflect the robustness of the results of a clinical trial. The Fragility Index (FI) was developed as a measure of how many outcome events would need to change to nonevents to render a significant P value nonsignificant (P ≥ 0.05). The FI of trials from other medical specialties is typically < 5. We aimed to determine the FI of pediatric anesthesiology randomized controlled trials (RCT) and to test for association with various characteristics of the included trials.
methodsWe conducted a comprehensive systematic search of high-impact anesthesia, surgical, and medical journals from the last 25 years for trials comparing an intervention between two groups with a statistically significant P value (< 0.05) for a dichotomous outcome. We also compared FI values for variables that reflect the quality and importance of a trial.
resultsThe median [interquartile range] FI was 3 [1-7] and correlated positively with the number of participants (r
conclusionsThe FI of published trials in pediatric anesthesiology is similarly low as in other medical specialties. Larger trials with more events and P values ≤ 0.01 were associated with a higher FI.
Indexed as
Identifiers
37286747What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.