Evidence map›Paper›PMID 37286742›Full record

ReviewNature reviews. Genetics2023

Transposable elements in mammalian chromatin organization.

Heather A Lawson, Yonghao Liang, Ting Wang

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Genetics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers.

0numbers the graph read from it
0cells of the map it votes in
81citing papers in PubMed
47.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

81 citing papers in PubMed, 110 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. The dark genome in cardiovascular medicine.European heart journal · 2026
    Review
  8. UnlockingNAR genomics and bioinformatics · 2026
    Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. The Encyclopedia of DNA Elements.bioRxiv : the preprint server for biology · 2026
    Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article

21 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Heather A LawsonDepartment of Genetics, Washington University School of Medicine, Saint Louis, MO, USA. lawson@wustl.edu.
Yonghao LiangDepartment of Genetics, Washington University School of Medicine, Saint Louis, MO, USA.
Ting WangDepartment of Genetics, Washington University School of Medicine, Saint Louis, MO, USA. twang@wustl.edu.ORCID 0000-0002-6800-242X
Washington University in St. Louis · USJames S. McDonnell Foundation · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Transposable elements (TEs) are mobile DNA elements that comprise almost 50% of mammalian genomic sequence. TEs are capable of making additional copies of themselves that integrate into new positions in host genomes. This unique property has had an important impact on mammalian genome evolution and on the regulation of gene expression because TE-derived sequences can function as cis-regulatory elements such as enhancers, promoters and silencers. Now, advances in our ability to identify and characterize TEs have revealed that TE-derived sequences also regulate gene expression by both maintaining and shaping 3D genome architecture. Studies are revealing how TEs contribute raw sequence that can give rise to the structures that shape chromatin organization, and thus gene expression, allowing for species-specific genome innovation and evolutionary novelty.

Indexed as

DNA Transposable ElementsRegulatory Sequences, Nucleic AcidAnimalsChromatinEvolution, MolecularMammalsPromoter Regions, GeneticChromatinDNA Transposable Elements

Identifiers

PMID37286742
OpenAlexW4379653175

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.