ArticleNature2023
Ptbp1 deletion does not induce astrocyte-to-neuron conversion.
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Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
–field-weighted citation impact
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed.
- Review
- Article
- Reverse the progression of Alzheimer's disease through Nano-ERASER-based adult neuroregeneration.Cell biomaterials · 2026Article
- A NeuroD1 AAV-Based Gene Therapy for Functional Brain Repair in Alzheimer's Disease-Like Non-Human Primate Model.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- The therapeutic potential and mechanisms of targeting the PTBP1/Nogo-A/NgR axis in PTSD induced by single prolonged stress in mice.Experimental & molecular medicine · 2026Article
- The Mechanisms and Application Prospects of Astrocyte Reprogramming into Neurons in Central Nervous System Diseases.Current neuropharmacology · 2026Review
- Article
- PTBP1 depletion in mature astrocytes reveals distinct splicing alterations without neuronal features.eLife · 2025Article
- Ptbp1 knockdown induces conversion of rat spinal cord astrocytes into neuron like cells.Scientific reports · 2025Article
- Comprehensive profiling of transcription factors for reprogramming human astrocytes to neuronal cells through endogenous CRISPR-based gene activation.bioRxiv : the preprint server for biology · 2025Article
- Ptbp1 is not required for retinal neurogenesis and cell fate specification.bioRxiv : the preprint server for biology · 2025Article
- PTBP1 Depletion in Mature Astrocytes Reveals Distinct Splicing Alterations Without Neuronal Features.bioRxiv : the preprint server for biology · 2025Article
- Depletion of Polypyrimidine tract binding protein 1 (ptbp1) activates Müller glia-derived proliferation during zebrafish retina regeneration via modulation of the senescence secretome.Experimental eye research · 2025Article
- Neurons derived from NeuroD1-expressing astrocytes transition through transit-amplifying intermediates but lack functional maturity.Science advances · 2025Article
- Ptbp1 Knockdown in Glial Cells Promotes Motor and Sensory Function Recovery After Peripheral Nerve Injury.CNS neuroscience & therapeutics · 2025Article
- Decoding gene networks controlling hypothalamic and prethalamic neuron development.Cell reports · 2025Article
- Transcriptome-wide alternative mRNA splicing analysis reveals post-transcriptional regulation of neuronal differentiation.The FEBS journal · 2025Article
- Investigating Müller glia reprogramming in mice: a retrospective of the last decade, and a look to the future.Neural regeneration research · 2025Article
- Decoding Gene Networks Controlling Hypothalamic and Prethalamic Neuron Development.bioRxiv : the preprint server for biology · 2025Article
- The interaction between resilience framework and neuron-astrocyte-synapse dynamics in AD.Frontiers in aging neuroscience · 2025Review
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Authors and funding
7 authors.
Thanh Hoang *Solomon H. Snyder Department of Neuroscience, John Hopkins University School of Medicine, Baltimore, MD, USA. thahoang@umich.edu.ORCID 0000-0002-7666-3842
Dong Won Kim *Solomon H. Snyder Department of Neuroscience, John Hopkins University School of Medicine, Baltimore, MD, USA. tkim@dandrite.au.dk.ORCID 0000-0001-8624-0168
Haley AppelSolomon H. Snyder Department of Neuroscience, John Hopkins University School of Medicine, Baltimore, MD, USA.
Manabu OzawaCenter for Experimental Medicine and Systems Biology, University of Tokyo, Tokyo, Japan.
Sika ZhengDivision of Biomedical Sciences, University of California, Riverside, Riverside, CA, USA.ORCID 0000-0002-0573-4981
Juhyun KimDepartment of Psychiatry and Behavioral Science, John Hopkins University School of Medicine, Baltimore, MD, USA.
Seth BlackshawSolomon H. Snyder Department of Neuroscience, John Hopkins University School of Medicine, Baltimore, MD, USA. sblack@jhmi.edu.ORCID 0000-0002-1338-8476
Funding
Use of systems pharmacology to prevent rod and cone photoreceptor degenerationR24EY027283 · NEI · UNIVERSITY OF CALIFORNIA-IRVINE · PI PALCZEWSKI, KRZYSZTOF · 2017 to 2021
$7.9MTranscriptional regulation of retinal cell differentiation and functionR01EY020560 · NEI · JOHNS HOPKINS UNIVERSITY · PI BLACKSHAW, SETH · 2011 to 2021
$4.4MComparative transcriptomic and epigenomic analyses of Muller glia reprogrammingU01EY027267 · NEI · UNIVERSITY OF NOTRE DAME · PI BLACKSHAW, SETH, HYDE, DAVID R · 2016 to 2019
$3.0MIdentification of gene regulatory networks that control proliferative and neurogenic competence in mammalian Müller gliaR01EY031685 · NEI · JOHNS HOPKINS UNIVERSITY · PI BLACKSHAW, SETH · 2020 to 2023
$2.0MIdentification of gene regulatory networks controlling temporal patterning in retinal progenitor cells and neurogenic Müller gliaR01EY036173 · NEI · JOHNS HOPKINS UNIVERSITY · PI Seth Blackshaw · 2024 to 2026
$2.0MNEI NIH HHS R01 EY020560NEI NIH HHS R01 EY031685NEI NIH HHS R01 EY036173NEI NIH HHS R24 EY027283NEI NIH HHS U01 EY027267
Abstract
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Indexed as
AstrocytesParkinson DiseaseHumansNeurons
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.