Evidence map›Paper›PMID 37286599›Full record

ArticleNature2023

Ultraviolet radiation shapes dendritic cell leukaemia transformation in the skin.

Gabriel K Griffin, Christopher A G Booth, Katsuhiro Togami, Sun Sook Chung, Daniel Ssozi, Julia A Verga, Juliette M Bouyssou, Yoke Seng Lee, Vignesh Shanmugam, Jason L Hornick and 6 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
9.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 59 citations in OpenAlex.

  1. Trial
  2. Pivekimab Sunirine in Blastic Plasmacytoid Dendritic Cell Neoplasm.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2026
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 1 country.

Gabriel K GriffinDepartment of Pathology, Dana-Farber Cancer Institute, Boston, MA, USA. gabriel_griffin@dfci.harvard.edu.ORCID 0000-0002-4042-6757
Christopher A G BoothDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.ORCID 0000-0003-3841-6637
Katsuhiro TogamiDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.ORCID 0000-0001-8422-0008
Sun Sook ChungDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.ORCID 0000-0002-7340-3359
Daniel SsoziBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Julia A VergaBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Juliette M BouyssouDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.ORCID 0000-0002-2301-0426
Yoke Seng LeeBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Vignesh ShanmugamBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Jason L HornickDepartment of Pathology, Brigham and Women's Hospital, Boston, MA, USA.ORCID 0000-0001-6475-8345
Nicole R LeBoeufDepartment of Dermatology, Center for Cutaneous Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Boston, MA, USA.
Elizabeth A MorganDepartment of Pathology, Brigham and Women's Hospital, Boston, MA, USA.
Bradley E BernsteinBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Volker HovestadtBroad Institute of MIT and Harvard, Cambridge, MA, USA. volker_hovestadt@dfci.harvard.edu.ORCID 0000-0002-3480-6649
Peter van GalenBroad Institute of MIT and Harvard, Cambridge, MA, USA. pvangalen@bwh.harvard.edu.ORCID 0000-0002-0735-1570
Andrew A LaneBroad Institute of MIT and Harvard, Cambridge, MA, USA. andrew_lane@dfci.harvard.edu.ORCID 0000-0001-7380-0226
Broad Institute · USDana-Farber Cancer Institute · USBrigham and Women's Hospital · US

Funding

Targeting blastic plasmacytoid dendritic cell neoplasm (BPDCN)R37CA225191 · NCI · DANA-FARBER CANCER INST · PI LANE, ANDREW A · 2018 to 2024
$3.0M
The role of epigenetic plasticity in acute myeloid leukemia cell persistenceR00CA218832 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI VAN GALEN, PETER · 2019 to 2021
$747k
NCI NIH HHS R00 CA218832NCI NIH HHS R37 CA225191
6 · The paper itself

Abstract

Tumours most often arise from progression of precursor clones within a single anatomical niche. In the bone marrow, clonal progenitors can undergo malignant transformation to acute leukaemia, or differentiate into immune cells that contribute to disease pathology in peripheral tissues

Indexed as

Cell Transformation, NeoplasticDendritic CellsLeukemia, Myeloid, AcuteSkinSkin NeoplasmsUltraviolet RaysBone Marrow CellsCell DeathCell LineageClone CellsDioxygenasesDNA-Binding ProteinsHumansMutationOrgan SpecificitySingle-Cell Gene Expression AnalysisDioxygenasesDNA-Binding ProteinsTET2 protein, human

Identifiers

PMID37286599
PMCPMC10284703
OpenAlexW4379645224

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.