ArticleNature2023
Epigenetic dysregulation from chromosomal transit in micronuclei.
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Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers.
0numbers the graph read from it
0cells of the map it votes in
76citing papers in PubMed
16.8field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
76 citing papers in PubMed, 111 citations in OpenAlex.
- Micronuclear ecDNA constrains tumor cell fitness and is associated with favorable patient survival.Nature genetics · 2026Article
- Genome instability goes mobile: damaged DNA transfer between human cells.Signal transduction and targeted therapy · 2026Article
- Chromosomal instability in cancer: sources, consequences and new therapeutic opportunities.Signal transduction and targeted therapy · 2026Review
- N-Terminal Basic Helix and S120 Phosphorylation Cooperatively Regulate Nuclear Localization of UBE2A/B in Mechanotransduction.Biology · 2026Article
- A versatile cGAMP reporter reveals principles of cGAS activation by DNA damage and chromosome instability.Nature cell biology · 2026Article
- Review
- BAP1 deficiency-induced SKA3 promotes clear cell renal cell carcinoma malignant progression by regulating chromosomal instability.Cell death & disease · 2026Article
- Cancer Heterogeneity and Cancer Cell Plasticity: Molecular Mechanisms and Precision Therapy.MedComm · 2026Review
- Molecular mechanisms regulating cGAS/STING activation in health and disease.The Journal of clinical investigation · 2026Review
- Nanotechnology-driven STING regulation for on-demand therapy.Acta pharmaceutica Sinica. B · 2026Review
- ECHOS enables spatial epigenome profiling at subcellular resolution.bioRxiv : the preprint server for biology · 2026Article
- Micronuclei: origins, assays, mechanisms, diseases and treatments.Signal transduction and targeted therapy · 2026Review
- Aneuploidy in exfoliated buccal cells: mechanisms, methods, and future perspectives.Mutagenesis · 2026Review
- Opportunities and challenges of targeting cGAS-STING in cancer.Nature reviews. Cancer · 2026Review
- Micronucleus quantification from whole-slide haematology images using AI serves as a translatable pharmacodynamic biomarker for DNA damage response inhibitors.Scientific reports · 2026Article
- PARP1 Suppression Drives ROS Resistance in Aneuploid Cancer Cells.bioRxiv : the preprint server for biology · 2026Article
- Tumor cell cycle regulation: integrated perspective of stage characteristics, regulatory networks, and signaling pathway intervention strategies.Molecular biomedicine · 2026Review
- Aluminum Genotoxicity in Plants, Mammals, and Unicellular Eukaryotes: The Underlying Mechanisms.International journal of molecular sciences · 2026Review
- The Gb3-synthase A4GALT is an epigenetically regulated driver of tumor invasiveness in gastrointestinal cancer.BMC cancer · 2026Article
- Epigenomics-guided precision oncology: Chromatin variants in prostate tumor evolution.International journal of cancer · 2026Review
16 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
32 authors at 12 institutions in 2 countries.
Albert S AgustinusHuman Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0000-0002-2700-6475
Duaa Al-Rawi *Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0000-0002-9218-6513
Bhargavi Dameracharla *Department of Computer Science, University of California, San Diego, La Jolla, CA, USA.
Ramya Raviram *New York Genome Center, New York, NY, USA.
Bailey S C L JonesDepartment of Ophthalmology and Visual Science, Yale University School of Medicine, New Haven, CT, USA.ORCID 0000-0003-0007-2074
Stephanie StranskyDepartment of Biochemistry, Albert Einstein College of Medicine, New York, NY, USA.ORCID 0000-0003-0844-2754
Lorenzo ScipioniSchool of Engineering, University of California, Irvine, Irvine, CA, USA.ORCID 0000-0003-2980-1912
Jens LuebeckDepartment of Computer Science, University of California, San Diego, La Jolla, CA, USA.ORCID 0000-0003-4391-979X
Melody Di BonaHuman Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0000-0002-8853-2604
Danguole NorkunaiteHuman Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Robert M MyersNew York Genome Center, New York, NY, USA.ORCID 0000-0003-1869-6467
Mercedes DuranHuman Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Seongmin ChoiComputational Oncology, Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Britta WeigeltDepartment of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0000-0001-9927-1270
Shira YomtoubianDepartment of Cell and Developmental Biology, Weill Cornell Medicine, New York, NY, USA.
Andrew McPhersonComputational Oncology, Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Eléonore ToufektchanMolecular Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Kristina KeuperDepartment of Molecular Genetics, University of Kaiserslautern, Kaiserslautern, Germany.ORCID 0000-0002-9841-5516
Paul S MischelDepartment of Pathology, School of Medicine, Stanford University, Stanford, CA, USA.ORCID 0000-0002-4560-2211
Vivek MittalHuman Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0000-0002-4764-7413
Sohrab P ShahComputational Oncology, Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0000-0001-6402-523X
John MaciejowskiMolecular Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0000-0001-8134-9308
Zuzana StorchovaDepartment of Molecular Genetics, University of Kaiserslautern, Kaiserslautern, Germany.ORCID 0000-0003-2376-7047
Enrico GrattonSchool of Engineering, University of California, Irvine, Irvine, CA, USA.
Peter LyDepartment of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0001-8946-7069
Dan LandauNew York Genome Center, New York, NY, USA.
Mathieu F BakhoumDepartment of Ophthalmology and Visual Science, Yale University School of Medicine, New Haven, CT, USA.
Richard P KocheCenter for Epigenetics Research, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0000-0002-6820-5083
Simone SidoliDepartment of Biochemistry, Albert Einstein College of Medicine, New York, NY, USA.ORCID 0000-0001-9073-6641
Vineet BafnaDepartment of Computer Science, University of California, San Diego, La Jolla, CA, USA.ORCID 0000-0002-5810-6241
Yael DavidPharmacology Graduate Program, Weill Cornell Medicine, New York, NY, USA. davidshy@mskcc.org.ORCID 0000-0003-1696-0025
Samuel F BakhoumHuman Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA. samuel.bakhoum@gmail.com.ORCID 0000-0002-4779-8422
Memorial Sloan Kettering Cancer Center · USUniversity of California San Diego · USAlbert Einstein College of Medicine · USCornell University · USUniversity of California, Irvine · USUniversity of Kaiserslautern · DENew York Genome Center · USStanford University · USThe University of Texas Southwestern Medical Center · USTri-Institutional PhD Program in Chemical Biology · USYale Cancer Center · USYale University · US
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4MYale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9MYale Pathology Tissue Services Shared ResourceP30CA016359 · NCI · YALE UNIVERSITY · PI MEGAN C KING · 1985 to 2026
$85.0MWeill Cornell/Rockefeller/Sloan-Kettering MST ProgramT32GM007739 · NIGMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI HSU, KATHARINE C · 1985 to 2023
$51.1MTargeting Polθ to Overcome PARP Inhibitor Resistance in Homologous Recombination Deficient Breast CancerP50CA247749 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI Simon N. Powell · 2020 to 2026
$16.3MInvestigational Cancer Therapeutics Training Program (ICTTP)T32CA009207 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Omar Abdel-Wahab, Alexander Drilon · 1985 to 2026
$13.7MTranslating Stress Response Targeted Therapy for B-Cell LymphomasP50CA192937 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI DALLA-FAVERA, RICCARDO, ZELENETZ, ANDREW D. · 2016 to 2020
$10.9MProbing cytosolic nucleic acid sensing pathways in cancerR01CA256188 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI LAUGHNEY, ASHLEY MARIE · 2021 to 2025
$3.5MSoftware and algorithms for elucidating the structure, function, and evolution of extrachromosomal DNAU24CA264379 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BAFNA, VINEET, MESIROV, JILL P. · 2021 to 2025
$3.5MComputational methods for detecting patterns of complex genomic variationR01GM114362 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Vineet Bafna · 2016 to 2026
$3.1MImmune control and genomic instability at micronucleiR37CA261183 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI JOHN MACIEJOWSKI · 2022 to 2026
$2.4MThe role of chromosomal instability in tumor evolutionDP5OD026395 · OD · SLOAN-KETTERING INST CAN RESEARCH · PI BAKHOUM, SAMUEL F · 2018 to 2022
$2.2MNCATS NIH HHS UL1 TR001863NCI NIH HHS P30 CA008748NCI NIH HHS P30 CA016359NCI NIH HHS P50 CA192937NCI NIH HHS P50 CA247749NCI NIH HHS R00 CA212290NCI NIH HHS R01 CA256188NCI NIH HHS R01 CA270102NCI NIH HHS R37 CA261183NCI NIH HHS T32 CA009207NCI NIH HHS U24 CA264379NIGMS NIH HHS R01 GM114362NIGMS NIH HHS R35 GM138386NIGMS NIH HHS T32 GM007739NIH HHS DP5 OD026395NIH HHS S10 OD030286NIMHD NIH HHS L32 MD017781
Abstract
Chromosomal instability (CIN) and epigenetic alterations are characteristics of advanced and metastatic cancers
Indexed as
Chromosomal InstabilityChromosomesChromosome SegregationEpigenesis, GeneticMicronuclei, Chromosome-DefectiveNeoplasmsAnimalsChromatinDNA Copy Number VariationsHistonesHumansMiceMitosisProtein Processing, Post-TranslationalChromatinHistones
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.