Evidence map›Paper›PMID 37286565›Full record

ArticleNature communications2023

Stabilization of pre-existing neurotensin receptor conformational states by β-arrestin-1 and the biased allosteric modulator ML314.

Fabian Bumbak, James B Bower, Skylar C Zemmer, Asuka Inoue, Miquel Pons, Juan Carlos Paniagua, Fei Yan, James Ford, Hongwei Wu, Scott A Robson and 4 more

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Platelet Activation Pathways Controlling Reversible Integrin αIIbβ3 Activation.TH open : companion journal to thrombosis and haemostasis · 2024
    Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 4 countries.

Fabian BumbakDepartment of Molecular and Cellular Biochemistry, Indiana University, Bloomington, IN, 47405, USA. fabian.bumbak@monash.edu.ORCID 0000-0003-2739-8197
James B Bower *Department of Molecular and Cellular Biochemistry, Indiana University, Bloomington, IN, 47405, USA.ORCID 0000-0002-7854-4927
Skylar C Zemmer *Department of Molecular and Cellular Biochemistry, Indiana University, Bloomington, IN, 47405, USA.
Asuka InoueGraduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Miyagi, 980-8578, Japan.ORCID 0000-0003-0805-4049
Miquel PonsBiomolecular NMR laboratory, Department of Inorganic and Organic Chemistry, Universitat de Barcelona (UB), 08028, Barcelona, Spain.ORCID 0000-0002-0586-8322
Juan Carlos PaniaguaDepartment of Materials Science and Physical Chemistry & Institute of Theoretical and Computational Chemistry (IQTCUB), Universitat de Barcelona (UB), 08028, Barcelona, Spain.
Fei YanDepartment of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, VIC, 3010, Australia.
James FordDepartment of Chemistry, Indiana University, Bloomington, IN, 47405-7102, USA.
Hongwei WuDepartment of Chemistry, Indiana University, Bloomington, IN, 47405-7102, USA.
Scott A RobsonDepartment of Molecular and Cellular Biochemistry, Indiana University, Bloomington, IN, 47405, USA.ORCID 0000-0002-0529-0399
Ross A D BathgateThe Florey Institute of Neuroscience and Mental Health and Department of Biochemistry and Pharmacology, The University of Melbourne, Parkville, VIC, 3010, Australia.ORCID 0000-0001-6301-861X
Daniel J ScottThe Florey Institute of Neuroscience and Mental Health and Department of Biochemistry and Pharmacology, The University of Melbourne, Parkville, VIC, 3010, Australia.ORCID 0000-0001-6332-2793
Paul R GooleyDepartment of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, VIC, 3010, Australia.ORCID 0000-0002-0323-449X
Joshua J ZiarekDepartment of Molecular and Cellular Biochemistry, Indiana University, Bloomington, IN, 47405, USA. jjziarek@gmail.com.ORCID 0000-0002-3740-9999
Indiana University Bloomington · USThe University of Melbourne · AUUniversitat de Barcelona · ESDiscovery Institute · USGeorgia Institute of Technology · USTohoku University · JP

Funding

INTEGRATIVE PREDOCTORAL TRAINING IN DRUG ABUSE RESEARCH AT INDIANA UNIVERSITYT32DA024628 · NIDA · TRUSTEES OF INDIANA UNIVERSITY · PI Andrea Grace Hohmann, Kenneth Mackie · 2008 to 2026
$3.1M
The role of dynamics in GPCR and arrestin allosteryR35GM143054 · NIGMS · TRUSTEES OF INDIANA UNIVERSITY · PI ZIAREK, JOSHUA JAMES · 2021 to 2025
$2.1M
Deciphering GPCR signal transduction through NMR structure and dynamics studiesR00GM115814 · NIGMS · TRUSTEES OF INDIANA UNIVERSITY · PI ZIAREK, JOSHUA JAMES · 2017 to 2019
$747k
NIDA NIH HHS T32 DA024628NIGMS NIH HHS R00 GM115814NIGMS NIH HHS R35 GM143054
6 · The paper itself

Abstract

The neurotensin receptor 1 (NTS

Indexed as

Receptors, G-Protein-CoupledReceptors, NeurotensinArrestinbeta-Arrestin 1beta-ArrestinsGTP-Binding ProteinsArrestinbeta-Arrestin 1beta-ArrestinsGTP-Binding ProteinsReceptors, G-Protein-CoupledReceptors, Neurotensin

Identifiers

PMID37286565
PMCPMC10247727
OpenAlexW4379767981

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.