Evidence map›Paper›PMID 37286361›Full record

ArticleNeurology2023

Impact of Seizures While Driving Prior to Diagnosis in People With Focal Epilepsy: Motor Vehicle Accidents and Time to Diagnosis.

Benjamin Bases, Sarah Barnard, Jacqueline A French, Jacob Pellinen, Human Epilepsy Project

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Benjamin BasesFrom the Tulane University Undergraduate School of Public Health and Tropical Medicine (B.B.), New Orleans, LA; Monash University School of Medicine (S.B.), Clayton, Australia; Department of Neurology (J.A.F.), NYU Langone Health, New York; and Department of Neurology (J.P.), University of Colorado School of Medicine, Aurora.
Sarah BarnardFrom the Tulane University Undergraduate School of Public Health and Tropical Medicine (B.B.), New Orleans, LA; Monash University School of Medicine (S.B.), Clayton, Australia; Department of Neurology (J.A.F.), NYU Langone Health, New York; and Department of Neurology (J.P.), University of Colorado School of Medicine, Aurora.
Jacqueline A FrenchFrom the Tulane University Undergraduate School of Public Health and Tropical Medicine (B.B.), New Orleans, LA; Monash University School of Medicine (S.B.), Clayton, Australia; Department of Neurology (J.A.F.), NYU Langone Health, New York; and Department of Neurology (J.P.), University of Colorado School of Medicine, Aurora.ORCID 0000-0002-8756-6546
Jacob PellinenFrom the Tulane University Undergraduate School of Public Health and Tropical Medicine (B.B.), New Orleans, LA; Monash University School of Medicine (S.B.), Clayton, Australia; Department of Neurology (J.A.F.), NYU Langone Health, New York; and Department of Neurology (J.P.), University of Colorado School of Medicine, Aurora. jacob.pellinen@cuanschutz.edu.ORCID 0000-0002-0747-7210
Human Epilepsy Project

Funding

NIH Prior Approval Process ProfessionalUL1TR002535 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2018 to 2022
$51.1M
NCATS NIH HHS UL1 TR002535
6 · The paper itself

Abstract

objectivesTo identify the type, frequency, and consequences of seizures while driving (SzWD) in people with epilepsy before diagnosis.

methodsWe performed a retrospective cohort study using the Human Epilepsy Project (HEP) to identify prediagnostic SzWD. Clinical descriptions from seizure diaries and medical records were used to classify seizure types and frequencies, time to diagnosis, and SzWD outcomes. Data were modeled using multiple logistic regression to assess for factors independently associated with SzWD.

results32 prediagnostic SzWD were reported among 23/447 (5.1%) participants. Of them, 7 (30.4%) had more than 1. Six participants (26.1%) experienced SzWD as their first lifetime seizure. Most SzWD were focal with impaired awareness (n = 27, 84.4%). Of participants who had motor vehicle accidents (MVAs), 6 (42.9%) had no recollection. SzWD led to hospitalization in 11 people. The median time from first seizure to first SzWD was 304 days (IQR = 0-4,056 days). The median time between first SzWD and diagnosis was 64 days (IQR = 10-176.5 days). Employment was associated with a 3.95-fold increased risk of SzWD (95% CI 1.2-13.2, DISCUSSION: This study identifies the consequences of seizure-related MVAs and hospitalizations people experience before epilepsy diagnosis. This highlights the need for further research aimed at improving seizure awareness and improving time to diagnosis.

Indexed as

Epilepsies, PartialEpilepsyAccidents, TrafficAnticonvulsantsHumansMotor VehiclesRetrospective StudiesSeizuresAnticonvulsants

Identifiers

PMID37286361
PMCPMC10558166

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.