Evidence map›Paper›PMID 37286351›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2023

Metastatic Infiltration of Nervous Tissue and Periosteal Nerve Sprouting in Multiple Myeloma-Induced Bone Pain in Mice and Human.

Marta Diaz-delCastillo, Oana Palasca, Tim T Nemler, Didde M Thygesen, Norma A Chávez-Saldaña, Juan A Vázquez-Mora, Lizeth Y Ponce Gomez, Lars Juhl Jensen, Holly Evans, Rebecca E Andrews and 11 more

Open access · greenAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
3.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Not Just Neurons: Pain Is Orchestrated in Partnership with Many Non-neuronal Cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Review
  6. The Periosteum in Health and Disease.Current osteoporosis reports · 2025
    Review
  7. Article
  8. Bone pain in fibrous dysplasia does not rely on aberrant sensory nerve sprouting or neuroma formation.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2025
    Article
  9. Article
  10. Review
  11. Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 8 institutions in 5 countries.

Marta Diaz-delCastilloDepartment of Drug Design and Pharmacology, University of Copenhagen, Copenhagen 2100, Denmark marta@forens.au.dk.ORCID 0000-0001-7719-6839
Oana PalascaNovo Nordisk Foundation Center for Protein Research, University of Copenhagen, Copenhagen 2200, Denmark.
Tim T NemlerDepartment of Drug Design and Pharmacology, University of Copenhagen, Copenhagen 2100, Denmark.
Didde M ThygesenDepartment of Drug Design and Pharmacology, University of Copenhagen, Copenhagen 2100, Denmark.
Norma A Chávez-SaldañaUnidad Académica Multidisciplinaria Reynosa Aztlan, Autonomic University of Tamaulipas, Reynosa 88740, Mexico.
Juan A Vázquez-MoraUnidad Académica Multidisciplinaria Reynosa Aztlan, Autonomic University of Tamaulipas, Reynosa 88740, Mexico.
Lizeth Y Ponce GomezUnidad Académica Multidisciplinaria Reynosa Aztlan, Autonomic University of Tamaulipas, Reynosa 88740, Mexico.
Lars Juhl JensenNovo Nordisk Foundation Center for Protein Research, University of Copenhagen, Copenhagen 2200, Denmark.
Holly EvansDepartment of Oncology & Metabolism, University of Sheffield, Sheffield S10 2RX, United Kingdom.
Rebecca E AndrewsDepartment of Oncology & Metabolism, University of Sheffield, Sheffield S10 2RX, United Kingdom.
Aritri MandalDepartment of Oncology & Metabolism, University of Sheffield, Sheffield S10 2RX, United Kingdom.
David NevesNETRIS Pharma, Lyon 69008, France.
Patrick MehlenNETRIS Pharma, Lyon 69008, France.
James P CarusoDepartment of Neuroscience and Center for Advanced Pain, The University of Texas at Dallas, Dallas, Texas 75080.
Patrick M DoughertyDepartment of Pain Medicine, Division of Anesthesiology, MD Anderson Cancer Center, Houston, Texas 77030.ORCID 0000-0002-2177-2734
Theodore J PriceDepartment of Neuroscience and Center for Advanced Pain, The University of Texas at Dallas, Dallas, Texas 75080.ORCID 0000-0002-6971-6221
Andrew ChantryDepartment of Oncology & Metabolism, University of Sheffield, Sheffield S10 2RX, United Kingdom.
Michelle A LawsonDepartment of Oncology & Metabolism, University of Sheffield, Sheffield S10 2RX, United Kingdom.
Thomas L AndersenDepartment of Forensic Medicine, Aarhus University, Aarhus 8870, Denmark.
Juan M Jimenez-AndradeUnidad Académica Multidisciplinaria Reynosa Aztlan, Autonomic University of Tamaulipas, Reynosa 88740, Mexico.
Anne-Marie HeegaardDepartment of Drug Design and Pharmacology, University of Copenhagen, Copenhagen 2100, Denmark.
University of Copenhagen · DKAutonomous University of Tamaulipas · MXSheffield Teaching Hospitals NHS Foundation Trust · GBNetris Pharma (France) · FRThe University of Texas at Dallas · USUniversity of Sheffield · GBThe University of Texas MD Anderson Cancer Center · USUniversity of Southern Denmark · DK

Funding

Anatomic, Physiologic and Transcriptomic Mechanisms of Neuropathic Pain in Human DRGR01NS111929 · NINDS · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI DOUGHERTY, PATRICK M, PRICE, THEODORE J. · 2020 to 2024
$3.4M
Role of senescence in multiple myeloma tumorigenesisU01AG075227 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI WEIVODA, MEGAN M. · 2021 to 2025
$2.0M
NIA NIH HHS U01 AG075227NINDS NIH HHS R01 NS111929
6 · The paper itself

Abstract

Multiple myeloma (MM) is a neoplasia of B plasma cells that often induces bone pain. However, the mechanisms underlying myeloma-induced bone pain (MIBP) are mostly unknown. Using a syngeneic MM mouse model, we show that periosteal nerve sprouting of calcitonin gene-related peptide (CGRP

Indexed as

Bone DiseasesMultiple MyelomaNerve TissueAnimalsGanglia, SpinalHumansMaleMicePainQuality of Lifecancer-painhematologymultiple myelomamyelomapainsprouting

Identifiers

PMID37286351
PMCPMC10359036
OpenAlexW4379619006

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.