ArticleAmerican journal of respiratory and critical care medicine2023
Blood Gene Expression and Immune Cell Subtypes Associated with Chronic Obstructive Pulmonary Disease Exacerbations.
Registry-linked trialOpen access · greenAbstract read
In one paragraph
Article in American journal of respiratory and critical care medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01969344 (Subpopulations and Intermediate Outcome Measures in COPD Study), which is not on this map. Cited by 24 papers.
0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
6.2field-weighted citation impact, top 3% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Subpopulations and Intermediate Outcome Measures in COPD Study
Who cites it
24 citing papers in PubMed, 24 citations in OpenAlex.
- Global, regional and national burden of chronic obstructive pulmonary disease and lower respiratory infection attributable to household air pollution and secondhand smoke from 1990 to 2021: an analysis of the Global Burden of Disease Study (GBD 2021).Journal of thoracic disease · 2026Article
- Advancing Precision Approaches to Chronic Obstructive Pulmonary Disease.Tuberculosis and respiratory diseases · 2026Review
- Immune-inflammatory vulnerability index for risk stratification in older adults with acute exacerbations of COPD: a prospective cohort study.BMC geriatrics · 2026Observational
- Vascular-related proteomic signatures in COPD with suspected pulmonary hypertension as predictors of FEV₁ impairment.Respiratory research · 2026Article
- The Evolving Landscape of COPD Typization.Medicina (Kaunas, Lithuania) · 2026Review
- Blood cell ratio biomarkers of systemic inflammation in chronic obstructive pulmonary disease.Respiratory research · 2026Article
- Integrative multi-omic analyses identify major axes of heterogeneity in chronic obstructive pulmonary disease and uncover their molecular contributors.medRxiv : the preprint server for health sciences · 2026Article
- Blood Cell Ratio Biomarkers of Non-type 2 Inflammation in Chronic Obstructive Pulmonary.Research square · 2026Article
- Multi-omics to study chronic respiratory diseases and viral infections.European respiratory review : an official journal of the European Respiratory Society · 2026Review
- Identification and Validation of Mannose Metabolism-Related Biomarkers in COPD Through Integrated Bioinformatics and Machine Learning Analysis: A Pilot Study.International journal of chronic obstructive pulmonary disease · 2026Article
- Stability of blood eosinophils during acute exacerbations in patients with chronic obstructive pulmonary disease.BMC pulmonary medicine · 2025Article
- Molecular determinants of lung function decline: a multi-level analysis of gene expression.Respiratory research · 2025Article
- Comprehensive profiling of smoke-induced T cells in mice implicates clonal γδT17 cells as a hallmark of COPD.Nature communications · 2025Article
- Identification of ferroptosis-related genes involved in chronic obstructive pulmonary disease based on bioinformatics analysis.Animal models and experimental medicine · 2025Article
- miRNA-mRNA network analysis identifies PAX5 as a potential regulator of adaptive immune response in COPD.bioRxiv : the preprint server for biology · 2025Article
- Natural killer cells in the lung: novel insight and future challenge in the airway diseases.ERJ open research · 2025Review
- Review
- Natural Killer Cells as a Further Insight into the Course of Chronic Obstructive Pulmonary Disease.Biomedicines · 2024Article
- Blood-based Transcriptomic and Proteomic Biomarkers of Emphysema.American journal of respiratory and critical care medicine · 2024Article
- Dissecting causal relationships between immune cells, plasma metabolites, and COPD: a mediating Mendelian randomization study.Frontiers in immunology · 2024Article
Corrections and comments
- Commented on by
Authors and funding
19 authors at 10 institutions in 2 countries.
Min Hyung RyuChanning Division of Network Medicine and.ORCID 0000-0003-3071-7363
Jeong H YunChanning Division of Network Medicine and.ORCID 0000-0002-4361-8295
Jarrett D MorrowChanning Division of Network Medicine and.ORCID 0000-0002-5670-5865
Aabida SaferaliChanning Division of Network Medicine and.
Peter CastaldiChanning Division of Network Medicine and.
Robert ChaseChanning Division of Network Medicine and.
Meryl StavChanning Division of Network Medicine and.
Zhonghui XuChanning Division of Network Medicine and.
Igor BarjaktarevicDivision of Pulmonary and Critical Care Medicine, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California.
MeiLan HanDivision of Pulmonary and Critical Care Medicine and.
Wassim LabakiDivision of Pulmonary and Critical Care Medicine and.
Yvonne J HuangDivision of Pulmonary and Critical Care Medicine and.ORCID 0000-0002-7497-6597
Stephanie ChristensonDivision of Pulmonary, Critical Care, Allergy, and Sleep Medicine, University of California, San Francisco, California.
Wanda O'NealMarsico Lung Institute, School of Medicine, University of North Carolina, Chapel Hill, North Carolina.
Russell BowlerDivision of Pulmonary and Critical Care Medicine, Department of Medicine, National Jewish Health, Denver, Colorado.ORCID 0000-0003-4651-363X
Don D SinCentre for Heart and Lung Innovation, St. Paul's Hospital, Vancouver, British Columbia, Canada.
Christine M FreemanDivision of Pulmonary and Critical Care Medicine and.
Jeffrey L CurtisDivision of Pulmonary and Critical Care Medicine and.
Craig P HershChanning Division of Network Medicine and.ORCID 0000-0002-1342-4334
Harvard University · USPulmonary and Critical Care Associates · USBrigham and Women's Hospital · USNational Jewish Health · USUniversity of British Columbia · CAUniversity of California, Los Angeles · USUniversity of California, San Francisco · USUniversity of Michigan · USUniversity of North Carolina at Chapel Hill · USVA Ann Arbor Healthcare System · US
Funding
Genetic Epidemiology of COPDU01HL089897 · NHLBI · NATIONAL JEWISH HEALTH · PI CRAPO, JAMES D · 2007 to 2021
$56.9MRespiratory Computational Discovery CoreP01HL114501 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI MARTINEZ, FERNANDO J · 2013 to 2025
$24.9MGenetic Epidemiology of COPDU01HL089856 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SILVERMAN, EDWIN K · 2007 to 2021
$20.7MUsing Integrative Genomics To Identify and Characterize Emphysema-Associated eQTLR01HL124233 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI CASTALDI, PETER · 2014 to 2024
$7.1MSputum Microbial Markers of Type 2-Low AsthmaR01AI129958 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HUANG, YVONNE JEAN · 2017 to 2021
$3.6MDefining a gene expression signature of airway disease, COPD exacerbations, and response to treatmentR01HL166231 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI CRAIG P HERSH · 2023 to 2026
$3.3MCOPD SUBTYPES AND EARLY PREDICTION USING INTEGRATIVE PROBABILISTIC GRAPHICAL MODELS R01HL157879R01HL157879 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BENOS, PANAGIOTIS V, SCIURBA, FRANK · 2021 to 2024
$2.9MProspective Health Outcomes and Inflammatory Biomarkers Associated with e-Cigarette UseR01HL147326 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI CASTALDI, PETER · 2019 to 2021
$1.5MIntegrative omics pipeline to identify novel COPD genes and pathwaysK25HL136846 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI MORROW, JARRETT · 2017 to 2021
$945kIntegrative 'Omics of Transcriptome Complexity in COPDK01HL157613 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SAFERALI, AABIDA · 2021 to 2025
$944kThe role of COPD genetic risk factor HHIP on lymphocytic inflammationK08HL146972 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI YUN, JEONG H · 2020 to 2024
$848kRegulatory T Cell Inhibition of Natural Killer Cells in COPDI01CX001553 · VA · VETERANS HEALTH ADMINISTRATION · PI Christine M Basmajian · 2017 to 2026
–CSRD VA I01 CX001553NHLBI NIH HHS K01 HL157613NHLBI NIH HHS K08 HL146972NHLBI NIH HHS K25 HL136846NHLBI NIH HHS P01 HL114501NHLBI NIH HHS R01 HL124233NHLBI NIH HHS R01 HL147326NHLBI NIH HHS R01 HL157879NHLBI NIH HHS R01 HL166231NHLBI NIH HHS U01 HL089856NHLBI NIH HHS U01 HL089897NIAID NIH HHS R01 AI129958
Abstract
PubMed holds no abstract for this paper.
Indexed as
CD8-Positive T-LymphocytesPulmonary Disease, Chronic ObstructiveDisease ProgressionHumansProspective StudiesTranscriptomechronic obstructive pulmonary diseasecirculating leukocytesCOPD exacerbationimmune phenotypingRNA sequencing
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
NCT01969344ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.