Evidence map›Paper›PMID 37286216›Full record

SynthesisEuropean respiratory review : an official journal of the European Respiratory Society2023

Clinical utility of WHO-recommended screening tools and development and validation of novel clinical prediction models for pulmonary tuberculosis screening among outpatients living with HIV: an individual participant data meta-analysis.

Ashar Dhana, Rishi K Gupta, Yohhei Hamada, Andre P Kengne, Andrew D Kerkhoff, Christina Yoon, Adithya Cattamanchi, Byron W P Reeve, Grant Theron, Gcobisa Ndlangalavu and 8 more

Open access · diamondAbstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in European respiratory review : an official journal of the European Respiratory Society, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. Performance of 2 Finger-Stick Blood Tests to Triage Adults With Symptoms of Pulmonary Tuberculosis: A Prospective Multisite Diagnostic Accuracy Study.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2025
    Trial
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 10 institutions in 5 countries.

Ashar DhanaDepartment of Medicine, University of Cape Town, Cape Town, South Africa ashardhana@live.com.
Rishi K GuptaInstitute for Global Health, University College London, London, UK.ORCID https://orcid.org/0000-0002-6257-1285
Yohhei HamadaInstitute for Global Health, University College London, London, UK.ORCID https://orcid.org/0000-0002-9845-4267
Andre P KengneNon-communicable Diseases Research Unit, South African Medical Research Council, Cape Town, South Africa.
Andrew D KerkhoffDivision of HIV, Infectious Diseases and Global Medicine, Zuckerberg San Francisco General Hospital and Trauma Center, University of California San Francisco, San Francisco, CA, USA.ORCID https://orcid.org/0000-0002-5023-6658
Christina YoonDepartment of Medicine, Division of Pulmonary and Critical Care Medicine and Center for Tuberculosis, University of California San Francisco, San Francisco, CA, USA.
Adithya CattamanchiDepartment of Medicine, Division of Pulmonary and Critical Care Medicine and Center for Tuberculosis, University of California San Francisco, San Francisco, CA, USA.
Byron W P ReeveDSI-NRF Centre of Excellence for Biomedical Tuberculosis Research, South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
Grant TheronDSI-NRF Centre of Excellence for Biomedical Tuberculosis Research, South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.ORCID https://orcid.org/0000-0002-9216-2415
Gcobisa NdlangalavuDSI-NRF Centre of Excellence for Biomedical Tuberculosis Research, South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
Robin WoodInstitute of Infectious Disease and Molecular Medicine (IDM), Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.ORCID https://orcid.org/0000-0002-4276-7117
Paul K DrainDepartments of Global Health, Medicine, and Epidemiology, University of Washington, Seattle, WA, USA.ORCID https://orcid.org/0000-0002-9569-4097
Claire J CalderwoodInstitute for Global Health, University College London, London, UK.
Mahdad NoursadeghiDivision of Infection and Immunity, University College London, London, UK.
Tom BoylesHelen Joseph Hospital, Johannesburg, South Africa.
Graeme MeintjesDepartment of Medicine, University of Cape Town, Cape Town, South Africa.
Gary MaartensDepartment of Medicine, University of Cape Town, Cape Town, South Africa.
David A BarrInstitute of Infection and Global Health, University of Liverpool, Liverpool, UK.
South African Medical Research Council · ZAUniversity of Cape Town · ZAUniversity College London · GBUniversity of California, San Francisco · USHelen Joseph Hospital · ZAJapan Anti Tuberculosis Association · JPLondon School of Hygiene & Tropical Medicine · GBSan Francisco General Hospital · USUniversity of Liverpool · GBUniversity of Washington · US

Funding

Feasibility and acceptability of a peer-led strategy to improve community tuberculosis case finding among non-household contacts in ZambiaK23AI157914 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KERKHOFF, ANDREW · 2021 to 2025
$999k
NIAID NIH HHS K23 AI157914
6 · The paper itself

Abstract

backgroundThe World Health Organization (WHO) recommends that outpatient people living with HIV (PLHIV) undergo tuberculosis screening with the WHO four-symptom screen (W4SS) or C-reactive protein (CRP) (5 mg·L

methodsFollowing a systematic review, we identified studies that recruited adult outpatient PLHIV irrespective of tuberculosis signs and symptoms or with a positive W4SS, evaluated CRP and collected sputum for culture. We used logistic regression to develop an extended CPM (which included CRP and other predictors) and a CRP-only CPM. We used internal-external cross-validation to evaluate performance.

resultsWe pooled data from eight cohorts (n=4315 participants). The extended CPM had excellent discrimination (C-statistic 0.81); the CRP-only CPM had similar discrimination. The C-statistics for WHO-recommended tools were lower. Both CPMs had equivalent or higher net benefit compared with the WHO-recommended tools. Compared with both CPMs, CRP (5 mg·L

conclusionsCRP sets the standard for tuberculosis screening among outpatient PLHIV. The choice between using CRP at 5 mg·L

Indexed as

HIV InfectionsTuberculosisTuberculosis, PulmonaryAdultChlorobenzenesC-Reactive ProteinHumansModels, StatisticalOutpatientsPrognosisSensitivity and SpecificitySulfides4-chlorophenyl methyl sulfideChlorobenzenesC-Reactive ProteinSulfides

Identifiers

PMID37286216
PMCPMC10245131
OpenAlexW4379768464

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.