Evidence map›Paper›PMID 37286192›Full record

ArticleHLA2023

Genotype List String 1.1: Extending the Genotype List String grammar for describing HLA and Killer-cell Immunoglobulin-like Receptor genotypes.

Steven J Mack, Daniel Schefzyk, Robert P Millius, Martin Maiers, Jill A Hollenbach, Jane Pollack, Michael L Heuer, Loren Gragert, Stephen R Spellman, Lisbeth A Guethlein and 8 more

Abstract read
In one paragraph

Article in HLA, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Steven J MackDepartment of Pediatrics, University of California, San Francisco, Oakland, California, USA.ORCID 0000-0001-9820-9547
Daniel SchefzykDKMS, Tübingen, Germany.
Robert P MilliusNational Marrow Donor Program, Minneapolis, Minnesota, USA.
Martin MaiersNational Marrow Donor Program, Minneapolis, Minnesota, USA.ORCID 0000-0002-0198-2064
Jill A HollenbachDepartment of Neurology, University of California, San Francisco, San Francisco, California, USA.
Jane PollackNational Marrow Donor Program, Minneapolis, Minnesota, USA.
Michael L HeuerNational Marrow Donor Program, Minneapolis, Minnesota, USA.
Loren GragertSchool of Medicine, Tulane University, New Orleans, Louisiana, USA.ORCID 0000-0002-5945-6518
Stephen R SpellmanCenter for International Blood and Marrow Transplant Research, National Marrow Donor Program/Be The Match, Minneapolis, Minnesota, USA.
Lisbeth A GuethleinSchool of Medicine, Stanford University, Stanford, California, USA.
Joel SchneiderNational Marrow Donor Program, Minneapolis, Minnesota, USA.
Werner BochtlerZentrales Knochenmarkspender-Register für Deutschland (ZKRD), Ulm, Germany.
Hans-Peter EberhardZentrales Knochenmarkspender-Register für Deutschland (ZKRD), Ulm, Germany.ORCID 0000-0002-2731-4486
James RobinsonAnthony Nolan Research Institute, Royal Free Campus, London, UK.ORCID 0000-0002-2187-5944
Steven G E MarshAnthony Nolan Research Institute, Royal Free Campus, London, UK.ORCID 0000-0003-2855-4120
Alexander H SchmidtDKMS, Tübingen, Germany.
Jan A HofmannDKMS, Tübingen, Germany.ORCID 0000-0002-3397-2514
Jürgen SauterDKMS, Tübingen, Germany.ORCID 0000-0001-8485-2945

Funding

Integrated Exchange and Storage of Current- and Future-Generation Immunogenomic DataR01AI128775 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JILL Allison HOLLENBACH, STEVEN JOHN MACK · 2017 to 2026
$4.5M
HLA Immunogenetics and kidney allograft outcomesR01AI173095 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI Malek Kamoun · 2023 to 2026
$3.1M
MHC and KIR Sequencing and Association Analyses in the iGeneTRAiN StudiesU01AI152960 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI KAMOUN, MALEK, KEATING, BRENDAN JAMES · 2020 to 2024
$2.8M
NIAID NIH HHS R01 AI128775NIAID NIH HHS R01 AI173095NIAID NIH HHS U01 AI152960
6 · The paper itself

Abstract

The Genotype List (GL) String grammar for reporting HLA and Killer-cell Immunoglobulin-like Receptor (KIR) genotypes in a text string was described in 2013. Since this initial description, GL Strings have been used to describe HLA and KIR genotypes for more than 40 million subjects, allowing these data to be recorded, stored and transmitted in an easily parsed, text-based format. After a decade of working with HLA and KIR data in GL String format, with advances in HLA and KIR genotyping technologies that have fostered the generation of full-gene sequence data, the need for an extension of the GL String system has become clear. Here, we introduce the new GL String delimiter "?," which addresses the need to describe ambiguity in assigning a gene sequence to gene paralogs. GL Strings that do not include a "?" delimiter continue to be interpreted as originally described. This extension represents version 1.1 of the GL String grammar.

Indexed as

ImmunoglobulinsReceptors, KIRAllelesGene FrequencyGenotypeHumansImmunoglobulinsReceptors, KIRGenotype List StringHLAKiller-cell Immunoglobulin-like Receptor

Identifiers

PMID37286192
PMCPMC10524834

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.