Evidence map›Paper›PMID 37286073›Full record

ArticleNeuropharmacology2023

Conditional deletion of CB2 cannabinoid receptors from peripheral sensory neurons eliminates CB2-mediated antinociceptive efficacy in a mouse model of carrageenan-induced inflammatory pain.

Kelsey G Guenther, Zhili Xu, Julian Romero, Cecilia J Hillard, Ken Mackie, Andrea G Hohmann

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuropharmacology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Cannabinoid CBBritish journal of pharmacology · 2025
    Review
  4. The cannabinoid CBNeuropharmacology · 2025
    Article
  5. Article
  6. Cannabinoid CBBiomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2024
    Article
  7. Targeting sensory neuron GPCRs for peripheral neuropathic pain.Trends in pharmacological sciences · 2023
    Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Kelsey G GuentherProgram in Neuroscience, Indiana University, Bloomington, IN, USA; Department of Psychological and Brain Sciences, Indiana University, Bloomington, IN, USA.
Zhili XuProgram in Neuroscience, Indiana University, Bloomington, IN, USA; Department of Psychological and Brain Sciences, Indiana University, Bloomington, IN, USA.
Julian RomeroFaculty of Experimental Sciences, Universidad Francisco de Vitoria, Madrid, Spain.
Cecilia J HillardDepartment of Pharmacology and Toxicology, Med. Col. of Wisconsin, Milwaukee, WI, USA.
Ken MackieProgram in Neuroscience, Indiana University, Bloomington, IN, USA; Department of Psychological and Brain Sciences, Indiana University, Bloomington, IN, USA; Gill Center for Biomolecular Science, Indiana University, Bloomington, IN, USA.
Andrea G HohmannProgram in Neuroscience, Indiana University, Bloomington, IN, USA; Department of Psychological and Brain Sciences, Indiana University, Bloomington, IN, USA; Gill Center for Biomolecular Science, Indiana University, Bloomington, IN, USA. Electronic address: hohmanna@indiana.edu.
Indiana University Bloomington · USMedical College of Wisconsin · USUniversidad Francisco de Vitoria · ES

Funding

Project 3 - In vivo pharmacology of cannabinoid receptor probesP01DA009158 · NIDA · UNIVERSITY OF CONNECTICUT STORRS · PI Alexandros Makriyannis · 1994 to 2026
$26.0M
CB2 Cannabinoid Mechanisms for Suppressing Opioid Tolerance and DependenceR01DA047858 · NIDA · TRUSTEES OF INDIANA UNIVERSITY · PI HOHMANN, ANDREA GRACE, MACKIE, KENNETH · 2019 to 2023
$2.6M
Role of CB2 in Analgesic MechanismsR01DA041229 · NIDA · TRUSTEES OF INDIANA UNIVERSITY · PI HOHMANN, ANDREA GRACE, MACKIE, KENNETH · 2016 to 2020
$1.8M
A Novel Mechanism for Decreasing Opioid RewardR21DA042584 · NIDA · TRUSTEES OF INDIANA UNIVERSITY · PI HOHMANN, ANDREA GRACE, REBEC, GEORGE VINCENT · 2016 to 2017
$392k
NIDA NIH HHS P01 DA009158NIDA NIH HHS R01 DA041229NIDA NIH HHS R01 DA047858NIDA NIH HHS R21 DA042584
6 · The paper itself

Abstract

CB

Indexed as

HyperalgesiaPainAnalgesicsAnimalsCarrageenanFemaleMaleMiceReceptor, Cannabinoid, CB1Receptor, Cannabinoid, CB2Receptors, CannabinoidSensory Receptor CellsAnalgesicsCarrageenanCnr2 protein, mouseReceptor, Cannabinoid, CB1Receptor, Cannabinoid, CB2Receptors, CannabinoidCannabinoidCB(2) receptorDorsal root ganglionInflammationPain

Identifiers

PMID37286073
PMCPMC10409300
OpenAlexW4379389705

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.