Evidence map›Paper›PMID 37286062›Full record

ArticleExperimental gerontology2023

Data-driven physical actigraphy patterns relate to cognitive and vascular health in older adults.

Emily W Paolillo, Shannon Y Lee, Anna VandeBunte, Rowan Saloner, Leslie S Gaynor, Nina Djukic, Torie Tsuei, Yann Cobigo, Joel H Kramer, Kaitlin B Casaletto

Abstract read
In one paragraph

Article in Experimental gerontology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Cardiovascular contributions to dementia: Examining sex differences and female-specific factors.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Emily W PaolilloMemory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, United States of America. Electronic address: Emily.Paolillo@ucsf.edu.
Shannon Y LeeMemory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, United States of America.
Anna VandeBunteMemory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, United States of America; Department of Psychology, Palo Alto University, United States of America.
Rowan SalonerMemory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, United States of America.
Leslie S GaynorMemory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, United States of America.
Nina DjukicMemory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, United States of America.
Torie TsueiMemory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, United States of America.
Yann CobigoMemory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, United States of America.
Joel H KramerMemory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, United States of America.
Kaitlin B CasalettoMemory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, United States of America.

Funding

Research Education ComponentP30AG062422 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Gil Dan Rabinovici · 2019 to 2026
$36.9M
Mechanisms of Executive Decline in Normal AgingR01AG032289 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Kaitlin B Casaletto, JOEL H KRAMER · 2009 to 2026
$8.3M
Biological Predictors Of Brain Aging Trajectories Diversity Supplement: African American Outreach And The Intersection Between Social Determinants Of Health And Biomarkers Of Degenerative DiseaseRF1AG032289 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KRAMER, JOEL H · 2020 to 2021
$5.3M
Unraveling the intersection of synaptic biology, lifestyle, and cognitive resilienceR01AG072475 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CASALETTO, KAITLIN B · 2021 to 2025
$4.3M
Effects of chronic inflammation on brain structure and functionR01AG048234 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KRAMER, JOEL H · 2015 to 2019
$3.2M
Can Behavior Shape Neural Health? Identifying Modifiable Factors to Prevent Cognitive Decline in AgeK23AG058752 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CASALETTO, KAITLIN B · 2018 to 2022
$994k
NIA NIH HHS K23 AG058752NIA NIH HHS P30 AG062422NIA NIH HHS R01 AG032289NIA NIH HHS R01 AG048234NIA NIH HHS R01 AG072475NIA NIH HHS RF1 AG032289
6 · The paper itself

Abstract

Health benefits of physical activity (PA) are well known; however, specific PA patterns that relate most strongly to cognitive aging outcomes are poorly understood. We characterized latent profiles of PA among older adults and examined associations with cognition and vascular burden. 124 functionally normal older adults wore a Fitbit™ for 30 days. Daily average step count, sedentary time (0 steps/min), and high-intensity time (≥120 steps/min) were calculated. Participants completed neurocognitive testing assessing cognitive domains of executive functioning and memory; medical history, from which vascular burden (i.e., a count of cardiovascular conditions) was calculated; and brain MRI (n = 44). Subgroups with similar PA patterns were identified via latent profile analysis. Three latent PA classes emerged: Class 1

Indexed as

ActigraphyWhite MatterAgedCognitionExecutive FunctionExerciseHumansMaleCardiovascularCerebrovascularExerciseFitbitHealthy agingNeuropsychology

Identifiers

PMID37286062
PMCPMC10335604

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.