Evidence map›Paper›PMID 37285872›Full record

ArticleNature2023

Cryo-EM structure of SARS-CoV-2 postfusion spike in membrane.

Wei Shi, Yongfei Cai, Haisun Zhu, Hanqin Peng, Jewel Voyer, Sophia Rits-Volloch, Hong Cao, Megan L Mayer, Kangkang Song, Chen Xu and 3 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers.

0numbers the graph read from it
0cells of the map it votes in
79citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

79 citing papers in PubMed.

  1. Article
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  7. Review
  8. Article
  9. Article
  10. Article
  11. TMPRSS2-mediated coronavirus spike activation and inhibition.Nature structural & molecular biology · 2026
    Article
  12. Article
  13. Recurrent SARS-CoV-2 Omicron broadly neutralizing humanized antibodies in different single human VProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article

19 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Wei Shi *Division of Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.ORCID 0000-0002-0741-6813
Yongfei CaiDivision of Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.
Haisun ZhuInstitute for Protein Innovation, Harvard Institutes of Medicine, Boston, MA, USA.ORCID 0000-0001-8395-9409
Hanqin PengDivision of Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.ORCID 0000-0002-5357-8215
Jewel VoyerDivision of Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.
Sophia Rits-VollochDivision of Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.
Hong CaoCodex BioSolutions, Rockville, MD, USA.
Megan L MayerThe Harvard Cryo-EM Center for Structural Biology, Boston, MA, USA.
Kangkang SongDepartment of Biochemistry & Molecular Biotechnology, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Chen XuDepartment of Biochemistry & Molecular Biotechnology, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Jianming LuCodex BioSolutions, Rockville, MD, USA.
Jun Zhang *Division of Molecular Medicine, Boston Children's Hospital, Boston, MA, USA. juzhang@crystal.harvard.edu.ORCID 0000-0002-1289-0624
Bing ChenDivision of Molecular Medicine, Boston Children's Hospital, Boston, MA, USA. bchen@crystal.harvard.edu.ORCID 0000-0002-8625-1657

Funding

Structure of the full-length spike protein of SARS-CoV-2 in the context of membraneR01AI147884 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI CHEN, BING · 2020 to 2024
$3.4M
NIAID NIH HHS R01 AI147884
6 · The paper itself

Abstract

The entry of SARS-CoV-2 into host cells depends on the refolding of the virus-encoded spike protein from a prefusion conformation, which is metastable after cleavage, to a lower-energy stable postfusion conformation

Indexed as

Cryoelectron MicroscopyLipid BilayersMembrane FusionSARS-CoV-2Spike Glycoprotein, CoronavirusCOVID-19Protein ConformationVirus InternalizationLipid BilayersSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.