ArticleGerontology2023
Risk Factors of Progression to Cognitive Frailty: Singapore Longitudinal Ageing Study 2.
Article in Gerontology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Predicting cognitive frailty in older adults: an explainable machine learning model integrating radiomics and clinical features.BMC medical informatics and decision making · 2026Article
- Transitions across the cognitive frailty spectrum and its association with anxiety in individuals aged 55 years and over: a 7 years longitudinal study.Scientific reports · 2025Article
- The independent association of social isolation and loneliness with cognitive frailty in Chinese older adults: a cross-sectional study.BMC public health · 2025Article
- Article
- Cognitive frailty and functional disability in older adults: A 10-year prospective cohort study in Japan.GeroScience · 2025Article
- Prevalence of cognitive frailty and its associated factors in a population of Iranian older adults.Aging clinical and experimental research · 2024Article
- Risk factors and a nomogram for predicting cognitive frailty in Chinese patients with lung cancer receiving drug therapy: A single-center cross-sectional study.Thoracic cancer · 2024Article
- Factors affecting cognitive frailty improvement and progression in Taiwanese older adults.BMC geriatrics · 2024Article
- Risk factors analysis of cognitive frailty among geriatric adults in nursing homes based on logistic regression and decision tree modeling.Frontiers in aging neuroscience · 2024Article
- Cognitive frailty in urban community-dwelling older adults: Associated physical and psychological risk factors.Journal of family & community medicineArticle
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Authors and funding
8 authors.
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No grant is acknowledged in the PubMed record.
Abstract
introductionCognitive frailty is associated with higher risk of dementia and adverse health outcomes. However, multidimensional factors that influence cognitive frailty transitions are not known. We aimed to investigate risk factors of incident cognitive frailty.
methodsProspective cohort study participants were community-dwelling adults without dementia and other degenerative disorders and baseline and follow-up, including N = 1,054 participants aged ≥55 free of cognitive frailty at baseline, with complete baseline (March 6, 2009, to June 11, 2013) and follow-up data at 3-5 years later (January 16, 2013, to August 24, 2018). Incident cognitive frailty was defined by one or more criteria of the physical frailty phenotype and <26 of Mini-Mental State Examination (MMSE) score. Potential risk factors assessed at baseline included demographic, socioeconomic, medical, psychological and social factors, and biochemical markers. Data were analyzed using least absolute shrinkage selection operator (LASSO) multivariable logistic regression models.
resultsA total of 51 (4.8%) participants, including 21 (3.5%) of the cognitively normal and physically robust participants, 20 (4.7%) of the prefrail/frail only, and 10 (45.4%) of cognitively impaired only, transited to cognitive frailty at follow-up. Risk factors for transition to cognitive frailty were having eye problem (OR = 2.6, 95% CI 1.24-5.43) and low HDL cholesterol (OR = 4.1, 95% CI 2.03-8.40), while protective factors for cognitive frailty transition were higher levels of education (OR = 0.3, 95% CI 0.10-0.74) and participation in cognitive stimulating activities (OR = 0.4, 95% CI 0.17-0.82).
conclusionMulti-domain modifiable factors especially related to leisure activities predict cognitive frailty transition and may be targeted for prevention of dementia and associated adverse health outcomes.
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