Evidence map›Paper›PMID 37285523›Full record

ArticleThe oncologist2023

Mogamulizumab-Associated Myositis With and Without Myasthenia Gravis and/or Myocarditis in Patients With T-Cell Lymphoma.

Cesar A Virgen, Jeffrey A Sparks, Anju Nohria, Meabh J O'Hare, Amrita Goyal, Jordan T Said, Marianne Tawa, Nicole R LeBoeuf, Thomas S Kupper, David C Fisher and 1 more

Open access · goldAbstract read
In one paragraph

Article in The oncologist, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Cesar A VirgenHarvard Medical School, Boston, MA, USA.ORCID 0000-0001-5273-7360
Jeffrey A SparksHarvard Medical School, Boston, MA, USA.ORCID 0000-0002-5556-4618
Anju NohriaHarvard Medical School, Boston, MA, USA.ORCID 0000-0002-7113-1118
Meabh J O'HareHarvard Medical School, Boston, MA, USA.
Amrita GoyalDepartment of Dermatology, University of Minnesota, Minneapolis, MN, USA.ORCID 0000-0003-3790-8242
Jordan T SaidHarvard Medical School, Boston, MA, USA.ORCID 0000-0002-0357-6916
Marianne TawaCenter for Cutaneous Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.ORCID 0000-0002-6548-9746
Nicole R LeBoeufHarvard Medical School, Boston, MA, USA.ORCID 0000-0002-8264-834X
Thomas S KupperHarvard Medical School, Boston, MA, USA.ORCID 0000-0002-4229-2916
David C FisherHarvard Medical School, Boston, MA, USA.ORCID 0000-0001-6915-8584
Cecilia LaroccaHarvard Medical School, Boston, MA, USA.
Brigham and Women's Hospital · USDana-Farber Cancer Institute · USHarvard University · USUniversity of Minnesota · US

Funding

Skin Homing T CellsR01AR065807 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI KUPPER, THOMAS S. · 2013 to 2022
$6.3M
NIAMS NIH HHS R01 AR065807
6 · The paper itself

Abstract

Mogamulizumab is being increasingly prescribed for the treatment of T-cell lymphomas (MF/SS/ATLL). We conducted a retrospective cohort study to identify muscular immune-related adverse events (irAEs) associated with mogamulizumab in patients with T-cell lymphoma followed at Dana-Farber Cancer Institute from January 2015 to June 2022. We identified 5 cases of mogamulizumab-associated myositis and/or myocarditis (MAM/Mc), 2 additionally affected by myasthenia gravis, among 42 patients with T-cell lymphoma. Three cases experienced -mogamulizumab-associated rash (MAR) prior to developing MAM/Mc. The incidence (n = 5/42, 11.9%) of muscular mogamulizumab-associated irAEs may be higher than has been previously reported in clinical trials and may be of late onset (a median of 5 cycles and as late as 100 days from the last infusion). We highlight the utility of IVIG, together with systemic corticosteroids, for the treatment of these potentially fatal side effects associated with mogamulizumab therapy.

Indexed as

Lymphoma, T-CellLymphoma, T-Cell, PeripheralMyasthenia GravisMyocarditisMyositisAntibodies, Monoclonal, HumanizedHumansRetrospective StudiesAntibodies, Monoclonal, Humanizedmogamulizumabcutaneouslymphomamogamulizumabmyasthenia gravismyocarditismyositisSezary syndromeT cell

Identifiers

PMID37285523
PMCPMC10400128
OpenAlexW4379746244

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.