ArticleJournal of cellular and molecular medicine2023
Elemi essential oil nanocapsulated drug ameliorates lung cancer via oxidative stress, apoptosis and inflammation pathway.
Article in Journal of cellular and molecular medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 16 citations in OpenAlex.
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- Preparation and evaluation of temozolomide loaded PLGA nanoparticles for the treatment of glioblastoma multiforme.Scientific reports · 2025Article
- Development of donepezil hydrochloride-loaded PLGA-based nanoparticles for Alzheimer's disease treatment.Scientific reports · 2025Article
- Preparation, Characterization, Antioxidant Activities, and Determination of Anti-Alzheimer Effects of PLGA-Based DDSs Containing Ferulic Acid.ACS omega · 2024Article
- Elemi essential oil nanocapsulated drug ameliorates lung cancer via oxidative stress, apoptosis and inflammation pathway.Journal of cellular and molecular medicine · 2023Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lung cancer is one of the most common causes of death in the world. Considering the severe side effects, toxicity and high costs of chemotherapeutics used in cancer treatment, there is a need for more economical and natural treatment methods such as essential oils. The purpose of this study is to determine the efficacy of Canarium commune (Elemi) essential oil (EO) and nanoparticles. Elemi EO is analysed by GC-FID/MS. The antiproliferative effect of Elemi EO and prepared nanoparticles on human lung adenocarcinoma (A549) and their effect on normal fibroblast cells (CCD-19Lu) were determined by the MTT test. The levels of TAS, TOS, CYCS, CASP3, TNF-α and IL-6 parameters of the experimental groups were determined using specific ELISA. BAX and Bcl-2 genes were studied with qRT-PCR to investigate the different ways that cancer cells undergo apoptosis. Limonene (53.7%), a-phellandrene (14.5%) and elemol (10.1%) were the major components of Elemi EO. 24-Hour IC
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