ArticleScience translational medicine2023
Chronic airway epithelial hypoxia exacerbates injury in muco-obstructive lung disease through mucus hyperconcentration.
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Article in Science translational medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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0cells of the map it votes in
47citing papers in PubMed
15.3field-weighted citation impact, top 1% of its field
What it found
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Who cites it
47 citing papers in PubMed, 59 citations in OpenAlex.
- The role of the respiratory microbiome in acute and chronic respiratory diseases.Nature reviews. Microbiology · 2026Review
- Chest CT imaging toward personalized management of chronic obstructive pulmonary disease, asthma, and bronchiectasis: pulmonologist perspectives.Japanese journal of radiology · 2026Review
- Airway mucus plugs in asthma and chronic obstructive pulmonary disease: pathobiology, imaging, and implications for clinical trials.American journal of respiratory and critical care medicine · 2026Review
- SARS-CoV-2 infection produces an IL-33-dependent chronic eosinophilic pneumonia and muco-inflammatory airways disease in Scnn1b-Tg mice.JCI insight · 2026Article
- Progress of Research on Cognitive Impairment in Patients With Chronic Obstructive Pulmonary Disease.Actas espanolas de psiquiatria · 2026Review
- Obstructive fibrinous tracheal pseudomembrane complicated with bronchial mucus plug: A rare post-intubation complication case report.Journal of anesthesia and translational medicine · 2026Article
- Structural and cellular mechanisms of mucus plugging in the larger airways.Chinese medical journal pulmonary and critical care medicine · 2026Review
- Influence of inflammation on drug transporter expression in human airway epithelia: Implications for inhaled drug pharmacokinetics.Drug metabolism and disposition: the biological fate of chemicals · 2026Article
- Associations Between Anemia and Obstructive Sleep Apnea in Patients with Cystic and Non-Cystic Bronchiectasis: A Prospective Cross-Sectional Study.Biomedicines · 2026Article
- Changes in sputum viscoelastic properties and airway inflammation in primary ciliary dyskinesia are comparable to cystic fibrosis on elexacaftor/tezacaftor/ivacaftor therapy.The European respiratory journal · 2026Article
- Human hypoxia models in aerospace medicine: Potential applications for human pharmacological research.British journal of clinical pharmacology · 2026Review
- Construction and Validation of a Machine Learning Model Based on Clinical and Microbiomic Features for Predicting High Mucus Secretion in COPD.International journal of chronic obstructive pulmonary disease · 2026Article
- Generation of hiPSC-Derived Brain Microvascular Endothelial Cells Using Directed Differentiation and Transcriptional Reprogramming.Arteriosclerosis, thrombosis, and vascular biology · 2026Article
- Total alkaloids ofFrontiers in pharmacology · 2026Article
- Lack of SLC26A9-mediated chloride secretion causes mucus plugging and severe respiratory distress in neonatal mice.JCI insight · 2025Article
- Bacteria enable tolerance to bile salt exposure in an immune-competent human intestinal model.Gut microbes · 2025Article
- STAT3-Dependent Regulation of CFTR and Ciliogenesis Is Essential for Mucociliary Clearance and Innate Airway Defense in Hyper-IgE Syndrome.American journal of respiratory and critical care medicine · 2025Article
- Hyperconcentrated mucus in small airways: a mechanistic model for the pathogenesis of paediatric bronchiectasis.European respiratory review : an official journal of the European Respiratory Society · 2025Review
- Article
- The immunology of asthma.Nature immunology · 2025Review
Corrections and comments
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Authors and funding
22 authors at 1 institution in 1 country.
Yu MikamiMarsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.ORCID 0000-0003-3262-2958
Barbara R GrubbMarsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.ORCID 0009-0005-8036-2937
Troy D RogersMarsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.ORCID 0009-0003-5509-5051
Hong DangMarsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.ORCID 0000-0002-7305-4208
Takanori AsakuraMarsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.ORCID 0000-0003-3122-6937
Pradeep KotaMarsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Rodney C GilmoreMarsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.ORCID 0000-0002-3821-8422
Kenichi OkudaMarsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.ORCID 0000-0001-9341-2730
Lisa C MortonMarsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.ORCID 0009-0000-3061-1652
Ling SunMarsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.ORCID 0000-0001-9040-4188
Gang ChenMarsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.ORCID 0000-0001-9533-6356
Jason A WykoffMarsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.ORCID 0000-0002-0201-5420
Camille EhreMarsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.ORCID 0000-0002-0046-0096
Juan VilarMarsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Catharina van HeusdenMarsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.ORCID 0009-0001-5403-5431
Alessandra Livraghi-ButricoMarsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.ORCID 0000-0001-8751-3631
Martina GentzschMarsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.ORCID 0000-0002-9435-0321
Brian ButtonMarsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.ORCID 0000-0001-8623-0576
M Jackson StuttsMarsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Scott H RandellMarsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.ORCID 0000-0001-5351-2841
Wanda K O'NealMarsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.ORCID 0000-0003-2412-5943
Richard C BoucherMarsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.ORCID 0000-0002-5745-3989
University of North Carolina at Chapel Hill · US
Funding
Vector CoreP30DK065988 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Scott H Randell · 2004 to 2026
$26.5MThe Biophysics of Mucus Hydration and Adhesion/CohesionP01HL108808 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BOUCHER, RICHARD CHARLES · 2012 to 2021
$23.9MSynthesis of Effective and Safe Mucolytics for Pulmonary DiseaseUH3HL123645 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BOUCHER, RICHARD CHARLES · 2016 to 2018
$4.6MMultiscale Biochemical/Biophysical Integration of Pulmonary Mucus TransportR01HL136961 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BOUCHER, RICHARD CHARLES · 2017 to 2020
$3.2MThe role of mucus and pulmonary surface interactions in lung defenseR01HL125280 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BUTTON, BRIAN M · 2015 to 2023
$3.1MThe molecular and cellular mechanisms of the STAT3 mutation-mediated pulmonary disorder in Autosomal Dominant Hyper IgE Syndrome (AD-HIES)U01HL156655 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BOUCHER, RICHARD CHARLES, CHEN, GANG · 2022 to 2025
$3.0MNHLBI NIH HHS P01 HL108808NHLBI NIH HHS R01 HL125280NHLBI NIH HHS R01 HL136961NHLBI NIH HHS U01 HL156655NHLBI NIH HHS UH3 HL123645NIDDK NIH HHS P30 DK065988
Abstract
Unlike solid organs, human airway epithelia derive their oxygen from inspired air rather than the vasculature. Many pulmonary diseases are associated with intraluminal airway obstruction caused by aspirated foreign bodies, virus infection, tumors, or mucus plugs intrinsic to airway disease, including cystic fibrosis (CF). Consistent with requirements for luminal O
Indexed as
COVID-19Cystic FibrosisPulmonary Disease, Chronic ObstructiveHumansHypoxiaLungMucus
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.