ArticlePLoS neglected tropical diseases2023
Temporal patterns, spatial risks, and characteristics of tegumentary leishmaniasis in Brazil in the first twenty years of the 21st Century.
Article in PLoS neglected tropical diseases, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Improved Treatment Outcome Following the Use of a Wound Dressings in Cutaneous Leishmaniasis Lesions.Pathogens (Basel, Switzerland) · 2024Trial
- Ethnic-Racial and Spatial Inequalities of American Cutaneous Leishmaniasis in Brazil: A Nationwide Analysis of Cumulative Notification and Mortality.Pathogens (Basel, Switzerland) · 2026Article
- Beyond the Skin: Topical Amphotericin B Nanocarriers Targeting Cutaneous Leishmaniasis with Suppression of Lymphatic Parasite Burden.Infectious disease reports · 2026Article
- Temporal trends and spatial distribution of leishmaniasis based on biomes in Brazil, 2007 to 2020.Revista do Instituto de Medicina Tropical de Sao Paulo · 2026Article
- Beyond Leishmania: hidden trypanosomatid diversity reveals complex parasite-sand fly networks in southeastern Brazil.Memorias do Instituto Oswaldo Cruz · 2026Article
- Co-endemicity of schistosomiasis and tegumentary leishmaniasis: Spatial co-clustering in endemic areas.Tropical medicine & international health : TM & IH · 2025Article
- Molecular Detection of Trypanosomatids in Rodents and Marsupials in the State of Amapá, Brazil.Microorganisms · 2025Article
- Ocurrence of Nyssomyia intermedia (Diptera: Psychodidae) in intradomiciliary environments: a potential vector of american cutaneous leishmaniasis in Montezuma, 2024.Epidemiologia e servicos de saude : revista do Sistema Unico de Saude do Brasil · 2025Article
- Spatial and temporal modeling of the global burden of Cutaneous Leishmaniasis in Brazil: A 21-year ecological study.PLoS neglected tropical diseases · 2024Article
- Oral Leishmaniasis in HIV-Positive and HIV-Negative Patients: A Comparative Analysis with Two New Case Reports.Head and neck pathology · 2024Article
- Tegumentary leishmaniasis in Brazil: priority municipalities and spatiotemporal relative risks from 2001 to 2020.Pathogens and global health · 2024Article
- Determining the relationship between dengue and vulnerability in a Brazilian city: a spatial modeling analysis.Pathogens and global health · 2024Article
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Authors and funding
12 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundTegumentary leishmaniasis (TL) is a significant public health issue in Brazil. The present ecological study describes the clinical and epidemiological characteristics of TL cases reported in the country, and analyzes the spatial and temporal patterns of the incidences and risks of occurrence across the five geopolitical regions and 27 federative units. METHODOLOGY/PRINCIPAL
findingsData regarding new cases of TL notified between 2001 and 2020 were obtained from the Information System for Notifiable Diseases of the Brazilian Ministry of Health. Joinpoint and spatial and temporal generalized additive models were used to establish trends in the evolution of TL during the target period. The incidence rate for the entire period was 226.41 cases/100,000 inhabitants. All regions of Brazil showed trends of decreasing incidence rates, albeit with fluctuations at specific times, with the exception of the Southeast where rates have increased since 2014, most particularly in Minas Gerais state. The disease was concentrated predominantly in the North region, with Acre state leading the incidence rank in the whole country, followed by Mato Grosso (Midwest), Maranhão and Bahia (Northeast) states. The spatial distribution of the risk of TL occurrence in relation to the annual averages was relatively stable throughout the period. The cutaneous form of TL was predominant and cases most frequently occurred in rural areas and among men of working age. The ages of individuals contracting TL tended to increase during the time series. Finally, the proportion of confirmations by laboratory tests was lower in the Northeast. CONCLUSION/SIGNIFICANCE: TL shows a declining trend in Brazil, but its widespread occurrence and the presence of areas with increasing incidence rates demonstrate the persistent relevance of this disease and the need for constant monitoring. Our findings reinforce the importance of temporal and spatial tools in epidemiologic surveillance routines and are valuable for targeting preventive and control actions.
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