SynthesisPloS one2023
Low skeletal muscle mass index and all-cause mortality risk in adults: A systematic review and meta-analysis of prospective cohort studies.
Synthesis in PloS one, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Defining Reference Values for Skeletal Muscle Metrics on Abdominal CT Using Data From Healthy Young Adult Populations: A Systematic Review and Meta-Analysis.AJR. American journal of roentgenology · 2025Pooled it
- Associations Between Exercise Training, Physical Activity, Sedentary Behaviour and Mortality: An Umbrella Review of Meta-Analyses.Journal of cachexia, sarcopenia and muscle · 2025Pooled it
- Pooled it
- Clinical Translation of Fisetin for Age-Related Diseases: Current Evidence and Future Opportunities.Nutrients · 2026Review
- Dietary Protein and the Risk of Mortality in Adults with Low Bone Mineral Density: A Longitudinal Study.Calcified tissue international · 2026Article
- Hypertrophic Effects of Single- versus Multi-Joint Exercise: A Direct Comparison between Knee Extension and Leg Press.Medicine and science in sports and exercise · 2026Article
- Factors Affecting Mandibular Movement During Mastication in Nursing Home Residents: A Two-Year Follow-Up Study.Nutrients · 2026Article
- Muscle Mass Moderates Metabolic Syndrome Risk Associated with Adiposity: A SHAP-Based Machine Learning Study.Nutrients · 2026Article
- L-shaped association of skeletal muscle mass with all-cause mortality among US adults: a population-based cohort study.Archives of public health = Archives belges de sante publique · 2026Article
- Integrating Sperm Microscopy, Environmental Exposures, and Lifestyle Factors for Male Fertility Analysis: Protocol for the Nippon Semen and Environmental Exposure Database (N-SEED) Cross-Sectional Study.JMIR research protocols · 2026Article
- No Differences in Muscular Adaptations to Long-Term Resistance Training Between Young Strict Vegetarian and Non-Vegetarian Women.Scandinavian journal of medicine & science in sports · 2026Article
- Association of estimated muscle mass and its changes with all-cause mortality: a Chinese population-based cohort study.BMC geriatrics · 2026Article
- Planetary health diet index and low muscle mass in adults aged 20-60 years: exploratory evaluation of a dairy-upweighted outcome-specific adaptation.Frontiers in nutrition · 2026Article
- Protein intake, physical activity, and skeletal muscle outcomes in middle-aged adults: an observational study from the US.Journal of nutritional science · 2026Observational
- Article
- Underexplored terrain: effects of high priority environmental toxicants on skeletal muscle.Journal of toxicology and environmental health. Part B, Critical reviews · 2026Review
- Association Between the Creatinine-to-Body Weight Ratio and All-Cause Mortality in a Rural Japanese Community.Cureus · 2025Article
- Unilateral isometric contraction induces REDD1 and suppresses insulin-stimulated mTORC1 and protein synthesis in non-contracted muscle of male mice.Physiological reports · 2025Article
- Equations for Assessing Body Composition by Ultrasound in Older Adults: A Narrative Review.Healthcare (Basel, Switzerland) · 2025Review
- Skeletal Muscle Mass Index and Body Fat Percentage Reflect Different Nutritional Markers Independent of BMI in Underweight Women.Nutrients · 2025Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe relationship between low skeletal muscle mass index (SMI) and all-cause mortality risk in the general adults remains unclear. Our study was conducted to examine and quantify the associations between low SMI and all-cause mortality risks.
methodsPubMed, Web of Science, and Cochrane Library for primary data sources and references to relevant publications retrieved until 1 April 2023. A random-effect model, subgroup analyses, meta-regression, sensitivity analysis, and publication bias were conducted using STATA 16.0.
resultsSixteen prospective studies were included in the meta-analysis of low SMI and the risk of all-cause mortality. A total of 11696 deaths were ascertained among 81358 participants during the 3 to 14.4 years follow-up. The pooled RR of all-cause mortality risk was 1.57 (95% CI, 1.25 to 1.96, P < 0.001) across the lowest to the normal muscle mass category. The results of meta-regression showed that BMI (P = 0.086) might be sources of heterogeneity between studies. Subgroup analysis showed that low SMI was significantly associated with an increased risk of all-cause mortality in studies with a body mass index (BMI) between 18.5 to 25 (1.34, 95% CI, 1.24-1.45, P<0.001), 25 to 30 (1.91, 95% CI, 1.16-3.15, P = 0.011), and over 30 (2.58, 95% CI, 1.20-5.54 P = 0.015).
conclusionsLow SMI was significantly associated with the increased risk of all-cause mortality, and the risk of all-cause mortality associated with low SMI was higher in adults with a higher BMI. Low SMI Prevention and treatment might be significant for reducing mortality risk and promoting healthy longevity.
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Registered trials
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