ArticleeLife2023
The locus coeruleus broadcasts prediction errors across the cortex to promote sensorimotor plasticity.
Article in eLife, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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Who cites it
52 citing papers in PubMed.
- Pharmacological and pupillary evidence for the noradrenergic contribution to reinforcement learning in Parkinson's disease.Communications biology · 2025Trial
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- Task-irrelevant stimuli robustly drive phasic pupil-linked arousal but only weakly affect memory formation.Scientific reports · 2026Article
- Association learning drives synaptic plasticity at feedforward synapses in somatosensory cortex.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- Complementary influences of noradrenaline and dopamine in orchestrating a motivated social behavior.Current opinion in neurobiology · 2026Review
- Insights into effortful adaptation during speech perception: The role of dopamine, norepinephrine, and prediction error.Cognitive, affective & behavioral neuroscience · 2026Review
- Voluntary Attention Selectively Modulates Omission Responses.Human brain mapping · 2026Article
- Global error signal guides local optimization in mismatch calculation.Nature communications · 2026Article
- Cortex-wide Dynamics of Internal Decisions About Behavioral Context.bioRxiv : the preprint server for biology · 2026Article
- Behavioral state-dependent norepinephrine dynamics in the primary somatosensory and prefrontal cortices during tactile detection tasks.bioRxiv : the preprint server for biology · 2026Article
- Leveraging insights from neuroscience to build adaptive artificial intelligence.Nature neuroscience · 2026Review
- Long Exhalations as Complementary Treatment for Chronic Pain: A Pilot Study.Journal of clinical medicine · 2025Article
- Long-term Locus Coeruleus Stimulation Exacerbates Tau Pathology in PS19 Mice.bioRxiv : the preprint server for biology · 2025Article
- The Somatosensory Mismatch Negativity.The European journal of neuroscience · 2025Review
- Environmental Novelty Modulates Rapid Cortical Plasticity During Navigation.bioRxiv : the preprint server for biology · 2025Article
- A Critical Look at Critical Periods.Annual review of vision science · 2025Review
- Duet model unifies diverse neuroscience experimental findings on predictive coding.bioRxiv : the preprint server for biology · 2025Article
- Locus coeruleus tonic upregulation increases selectivity to inconspicuous auditory information in autistic compared to non-autistic individuals: a combined pupillometry and electroencephalography study.Molecular autism · 2025Article
- Activity in serotonergic axons in visuomotor areas of cortex is modulated by the recent history of visuomotor coupling.Peer community journal · 2025Article
- Phase synchrony between prefrontal noradrenergic and cholinergic signals indexes inhibitory control.Nature communications · 2025Article
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2 authors.
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Abstract
Prediction errors are differences between expected and actual sensory input and are thought to be key computational signals that drive learning related plasticity. One way that prediction errors could drive learning is by activating neuromodulatory systems to gate plasticity. The catecholaminergic locus coeruleus (LC) is a major neuromodulatory system involved in neuronal plasticity in the cortex. Using two-photon calcium imaging in mice exploring a virtual environment, we found that the activity of LC axons in the cortex correlated with the magnitude of unsigned visuomotor prediction errors. LC response profiles were similar in both motor and visual cortical areas, indicating that LC axons broadcast prediction errors throughout the dorsal cortex. While imaging calcium activity in layer 2/3 of the primary visual cortex, we found that optogenetic stimulation of LC axons facilitated learning of a stimulus-specific suppression of visual responses during locomotion. This plasticity - induced by minutes of LC stimulation - recapitulated the effect of visuomotor learning on a scale that is normally observed during visuomotor development across days. We conclude that prediction errors drive LC activity, and that LC activity facilitates sensorimotor plasticity in the cortex, consistent with a role in modulating learning rates.
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