Evidence map›Paper›PMID 37285009›Full record

ArticleGeroScience2024

Serum neurofilament light and white matter characteristics in the general population: a longitudinal analysis.

Marco Hermesdorf, Niklas Wulms, Aleksandra Maceski, David Leppert, Pascal Benkert, Heinz Wiendl, Jens Kuhle, Klaus Berger

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in GeroScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Marco HermesdorfInstitute of Epidemiology and Social Medicine, University of Münster, Münster, Germany. hermesdorf@uni-muenster.de.ORCID 0000-0003-3541-7212
Niklas WulmsInstitute of Epidemiology and Social Medicine, University of Münster, Münster, Germany.
Aleksandra MaceskiMultiple Sclerosis Centre, Neurology, Departments of Head, Spine and Neuromedicine, Biomedicine and Clinical Research, University Hospital Basel and University of Basel, Basel, Switzerland.
David LeppertMultiple Sclerosis Centre, Neurology, Departments of Head, Spine and Neuromedicine, Biomedicine and Clinical Research, University Hospital Basel and University of Basel, Basel, Switzerland.
Pascal BenkertClinical Trial Unit, Department of Clinical Research, University Hospital Basel and University of Basel, Basel, Switzerland.
Heinz WiendlDepartment of Neurology With Institute of Translational Neurology, University Hospital Münster, Münster, Germany.
Jens KuhleMultiple Sclerosis Centre, Neurology, Departments of Head, Spine and Neuromedicine, Biomedicine and Clinical Research, University Hospital Basel and University of Basel, Basel, Switzerland.
Klaus BergerInstitute of Epidemiology and Social Medicine, University of Münster, Münster, Germany.
University of Basel · CHUniversity of Münster · DEUniversity Hospital Münster · DE

Funding

Bundesministerium für Bildung und Forschung FKZ-01ER0816Bundesministerium für Bildung und Forschung FKZ-01ER1205Bundesministerium für Bildung und Forschung FKZ-01ER1506
6 · The paper itself

Abstract

Neurofilament light polypeptide (NfL) is a component of the neuronal cytoskeleton and particularly abundant in large-caliber axons. When axonal injury occurs, NfL is released and reaches the cerebrospinal fluid and the blood. Associations between NfL and white matter alterations have previously been observed in studies based on patients with neurological diseases. The current study aimed to explore the relationship between serum NfL (sNfL) and white matter characteristics in a population-based sample. The cross-sectional associations between sNfL as dependent variable, fractional anisotropy (FA), and white matter lesion (WML) volume were analyzed with linear regression models in 307 community-dwelling adults aged between 35 and 65 years. These analyses were repeated with additional adjustment for the potential confounders age, sex, and body mass index (BMI). Longitudinal associations over a mean follow-up of 5.39 years were analyzed with linear mixed models. The unadjusted cross-sectional models yielded significant associations between sNfL, WML volume, and FA, respectively. However, after the adjustment for confounders, these associations did not reach significance. In the longitudinal analyses, the findings corroborated the baseline findings showing no significant associations between sNfL and white matter macrostructure and microstructure beyond the effects of age. In synopsis with previous studies in patients with acute neurological diseases showing a significant association of sNfL with white matter changes beyond the effects of age, the present results based on a sample from the general population suggest the perspective that changes in sNfL reflect age-related effects that also manifest in altered white matter macrostructure and microstructure.

Indexed as

Vascular DiseasesWhite MatterAgedBrainCross-Sectional StudiesHumansIntermediate FilamentsNeurofilament ProteinsNeurofilament ProteinsAgeAgingDiffusion tensor imagingFractional anisotropyNeurofilament lightWhite matter lesions

Identifiers

PMID37285009
PMCPMC10828306
OpenAlexW4379599928

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.