Evidence map›Paper›PMID 37284878›Full record

ArticleBiomedical microdevices2023

High-throughput microbead assay system with a portable, cost-effective Wi-Fi imaging module, and disposable multi-layered microfluidic cartridges for virus and microparticle detection, and tracking.

Jorge Manrique Castro, Frank Sommerhage, Rishika Khanna, Andre Childs, David DeRoo, Swaminathan Rajaraman

Open access · bronzeAbstract read
In one paragraph

Article in Biomedical microdevices, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Innovative Advances in Droplet Microfluidics.Research (Washington, D.C.) · 2025
    Review
  3. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Jorge Manrique CastroNanoScience Technology Center, University of Central Florida, Orlando, FL, 32816, USA.
Frank SommerhagePrimordia Biosystems, Costa Mesa, CA, USA.
Rishika KhannaDepartment of Mechanical Engineering, Indian Institute of Technology, Delhi, New Delhi, India.
Andre ChildsNanoScience Technology Center, University of Central Florida, Orlando, FL, 32816, USA.
David DeRooPrimordia Biosystems, Costa Mesa, CA, USA.
Swaminathan RajaramanNanoScience Technology Center, University of Central Florida, Orlando, FL, 32816, USA. swaminathan.rajaraman@ucf.edu.
University of Central Florida · USIndian Institute of Technology Delhi · IN

Funding

Rolosense: An innovative platform for automatic mobile phone readout of active SARS-CoV-2 particles (RADx-rad / SEED Administrative Supplement)U01AA029345 · NIAAA · EMORY UNIVERSITY · PI SALAITA, KHALID S. · 2021 to 2022
$1.4M
NIAAA NIH HHS U01 AA029345
6 · The paper itself

Abstract

In recent years biomedical scientific community has been working towards the development of high-throughput devices that allow a reliable, rapid and parallel detection of several strains of virus or microparticles simultaneously. One of the complexities of this problem lies on the rapid prototyping of new devices and wireless rapid detection of small particles and virus alike. By reducing the complexity of microfluidics microfabrication and using economic materials along with makerspace tools (Kundu et al. 2018) it is possible to provide an affordable solution to both the problems of high-throughput devices and detection technologies. We present the development of a wireless, standalone device and disposable microfluidics chips that rapidly generate parallel readouts for selected, possible virus variants from a nasal or saliva sample, based on motorized and non-motorized microbeads detection, and imaging processing of the motion tracks of these beads in micrometers. Microbeads and SARS-CoV-2 COVID-19 Delta variant were tested as proof-of-concept for testing the microfluidic cartridges and wireless imaging module. The Microbead Assay (MA) system kit consists of a Wi-Fi readout module, a microfluidic chip, and a sample collection/processing sub-system. Here, we focus on the fabrication and characterization of the microfluidic chip to multiplex various micrometer-sized beads for economic, disposable, and simultaneous detection of up to six different viruses, microparticles or variants in a single test, and data collection using a commercially available, Wi-Fi-capable, and camera integrated device (Fig. 1).

Indexed as

COVID-19Microfluidic Analytical TechniquesCost-Benefit AnalysisHumansLab-On-A-Chip DevicesMicrofluidicsMicrospheresSARS-CoV-2High-throughput assayMicrofluidic systemMicroparticle trackingMultilayered chipVirus detection

Identifiers

PMID37284878
PMCPMC10244845
OpenAlexW4379599667

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.