Palladium-catalyzed enantioselective three-component synthesis of α-arylglycine derivatives from glyoxylic acid, sulfonamides and aryltrifluoroborates.

Bastian Jakob, Nico Schneider, Luca Gengenbach, Georg Manolikakes

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Article in Beilstein journal of organic chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed

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1 citing paper in PubMed.

Catalytic multi-step domino and one-pot reactions.Beilstein journal of organic chemistry · 2024
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4 authors.

Bastian JakobDepartment of Chemistry, RPTU Kaiserslautern-Landau, Erwin-Schrödinger-Str. Geb. 54, D-67663 Kaiserslautern, Germany.

Nico Schneider *Department of Chemistry, RPTU Kaiserslautern-Landau, Erwin-Schrödinger-Str. Geb. 54, D-67663 Kaiserslautern, Germany.

Luca Gengenbach *Department of Chemistry, RPTU Kaiserslautern-Landau, Erwin-Schrödinger-Str. Geb. 54, D-67663 Kaiserslautern, Germany.

Georg ManolikakesDepartment of Chemistry, RPTU Kaiserslautern-Landau, Erwin-Schrödinger-Str. Geb. 54, D-67663 Kaiserslautern, Germany.ORCID https://orcid.org/0000-0002-4013-5757

Funding

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6 · The paper itself

Abstract

A palladium-catalyzed enantioselective three-component reaction of glyoxylic acid, sulfonamides and aryltrifluoroborates is described. This process provides modular access to the important α-arylglycine motif in moderate to good yields and enantioselectivies. The formed α-arylglycine products constitute useful building blocks for the synthesis of peptides or arylglycine-containing natural products.

Indexed as

amino acidsasymmetric catalysismulticomponent reactionpalladium catalysisPetasis reactionsulfonamides

Identifiers

PMID37284589

DOI10.3762/bjoc.19.52

PMCPMC10241097

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