Evidence map›Paper›PMID 37284521›Full record

ArticlePulmonary circulation2023

Muscle strength is reduced in children with pulmonary arterial hypertension.

Shari Pepplinkhuizen, Graziella Eshuis, Willemijn M H Zijlstra, Carola Y Timmer, Mark Jan Ploegstra, Otto T H M Lelieveld, Ann Marjolein Hepping, Ernesto A C Beenakker, Rolf M F Berger

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pulmonary circulation, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Shari PepplinkhuizenDepartment of Pediatric Cardiology, Center for Congenital Heart Disease, Beatrix Children's Hospital, University Medical Center Groningen University of Groningen Groningen The Netherlands.
Graziella EshuisDepartment of Pediatric Cardiology, Center for Congenital Heart Disease, Beatrix Children's Hospital, University Medical Center Groningen University of Groningen Groningen The Netherlands.ORCID https://orcid.org/0000-0001-6469-1566
Willemijn M H ZijlstraDepartment of Pediatric Cardiology, Center for Congenital Heart Disease, Beatrix Children's Hospital, University Medical Center Groningen University of Groningen Groningen The Netherlands.
Carola Y TimmerDepartment of Rehabilitation, University Medical Center Groningen University of Groningen Groningen The Netherlands.
Mark Jan PloegstraDepartment of Pediatric Cardiology, Center for Congenital Heart Disease, Beatrix Children's Hospital, University Medical Center Groningen University of Groningen Groningen The Netherlands.
Otto T H M LelieveldDepartment of Rehabilitation, University Medical Center Groningen University of Groningen Groningen The Netherlands.
Ann Marjolein HeppingDepartment of Orthopedics, University Medical Center Groningen University of Groningen, Groningen The Netherlands.
Ernesto A C BeenakkerDepartment of Neurology Medical Center Leeuwarden Groningen The Netherlands.ORCID https://orcid.org/0000-0001-7786-0285
Rolf M F BergerDepartment of Pediatric Cardiology, Center for Congenital Heart Disease, Beatrix Children's Hospital, University Medical Center Groningen University of Groningen Groningen The Netherlands.
University Medical Center Groningen · NLMedisch Centrum Leeuwarden · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Muscle strength is decreased in adults with pulmonary arterial hypertension (PAH). We aim to investigate muscle strength in children with PAH in relation to a cohort of healthy children, and investigate correlations with disease severity markers. This prospective study included children with PAH aged 4-18 years, who visited the Dutch National Referral Center for Pulmonary Hypertension in Childhood between October 2015 and March 2016. Muscle strength was assessed using handgrip strength and maximum voluntary isometric contractility (MVIC) of four peripheral muscles. Dynamic muscle function was evaluated with the Bruininks-Oseretsky test of motor proficiency (BOT-2). These measurements were compared with those in two cohorts of healthy children and correlated with 6-minute walk distance (6MWD), World Health Organization functional class (WHO-FC), N-terminal pro-brain natriuretic peptide (NT-proBNP), and time since diagnosis. Eighteen children with PAH aged 14.0 [interquartile range: 9.9-16.0] years showed reduced muscle strength. Handgrip strength

Indexed as

cardiopulmonary physiology and pathophysiologymusclepulmonary arterial hypertension

Identifiers

PMID37284521
PMCPMC10241349
OpenAlexW4379599024

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.