Evidence map›Paper›PMID 37284459›Full record

ArticleTheranostics2023

PCSK9 attenuates efferocytosis in endothelial cells and promotes vascular aging.

Shijie Liu, Jinzi Wu, Amanda Stolarz, Huiliang Zhang, Marjan Boerma, Stephanie D Byrum, Nancy J Rusch, Zufeng Ding

Open access · goldAbstract read
In one paragraph

Article in Theranostics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 1 pooled it
8.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Shijie LiuDepartment of Pharmacology and Toxicology, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
Jinzi WuDepartment of Pharmacology and Toxicology, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
Amanda StolarzDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
Huiliang ZhangDepartment of Pharmacology and Toxicology, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
Marjan BoermaDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
Stephanie D ByrumDepartment of Biochemistry and Molecular Biology, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
Nancy J RuschDepartment of Pharmacology and Toxicology, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
Zufeng DingDepartment of Pharmacology and Toxicology, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
University of Arkansas for Medical Sciences · US

Funding

Translational Regulation in Normal Erythropoiesis and Diamond Blackfan AnemiaP20GM121293 · NIGMS · ARKANSAS CHILDREN'S HOSPITAL RES INST · PI Alan Tackett, Sean D. Taverna · 2017 to 2026
$27.6M
Supplement for Google cloud build-outR24GM137786 · NIGMS · UNIV OF ARKANSAS FOR MED SCIS · PI Alan Tackett · 2020 to 2026
$15.4M
Impact of hemodynamics on efferocytosis in endothelial cellsR01HL162958 · NHLBI · UNIV OF ARKANSAS FOR MED SCIS · PI Zufeng Ding · 2022 to 2026
$1.7M
Mechanisms of PCSK9 in endothelial agingR21AG075548 · NIA · UNIV OF ARKANSAS FOR MED SCIS · PI DING, ZUFENG · 2022 to 2023
$418k
NHLBI NIH HHS R01 HL162958NIA NIH HHS R21 AG075548NIGMS NIH HHS P20 GM121293NIGMS NIH HHS R24 GM137786
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Endothelial CellsProprotein Convertase 9AgingAnimalsHumansMaleMiceNF-kappa BNF-kappa BPCSK9 protein, humanProprotein Convertase 9efferocytosisendothelial cellsPCSK9vascular aging

Identifiers

PMID37284459
PMCPMC10240829
OpenAlexW4379598212

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.