ArticleNeurophotonics2023
Using depth-enhanced diffuse correlation spectroscopy and near-infrared spectroscopy to isolate cerebral hemodynamics during transient hypotension.
Article in Neurophotonics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 15 citations in OpenAlex.
- Reproducibility of a time-resolved NIRS, multidistance diffuse correlation spectroscopy system: towards noninvasive longitudinal neuromonitoring.Neurophotonics · 2026Article
- Noninvasive estimation of superficial layer thickness using multi-channel diffuse correlation spectroscopy.Biomedical optics express · 2025Article
- Beneath the surface: revealing deep-tissue blood flow in human subjects with massively parallelized diffuse correlation spectroscopy.Neurophotonics · 2025Article
- Cerebral Blood Flow in Orthostatic Intolerance.Journal of the American Heart Association · 2025Review
- How the heterogeneity of the severely injured brain affects hybrid diffuse optical signals: case examples and guidelines.Neurophotonics · 2024Article
- All-optics technique for monitoring absolute cerebral blood flow: validation against magnetic resonance imaging perfusion.Neurophotonics · 2024Article
- Modified Beer-Lambert algorithm to measure pulsatile blood flow, critical closing pressure, and intracranial hypertension.Biomedical optics express · 2024Article
- Assessing changes in regional cerebral hemodynamics in adults with a high-density full-head coverage time-resolved near-infrared spectroscopy device.Journal of biomedical optics · 2024Article
- Comparison of diffuse correlation spectroscopy analytical models for measuring cerebral blood flow in adults.Journal of biomedical optics · 2023Article
- Characterization of cerebral macro- and microvascular hemodynamics during transient hypotension.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Significance: Combining diffuse correlation spectroscopy (DCS) and near-infrared spectroscopy (NIRS) permits simultaneous monitoring of multiple cerebral hemodynamic parameters related to cerebral autoregulation; however, interpreting these optical measurements can be confounded by signal contamination from extracerebral tissue. Aim: We aimed to evaluate extracerebral signal contamination in NIRS/DCS data acquired during transient hypotension and assess suitable means of separating scalp and brain signals. Approach: A hybrid time-resolved NIRS/multidistance DCS system was used to simultaneously acquire cerebral oxygenation and blood flow data during transient orthostatic hypotension induced by rapid-onset lower body negative pressure (LBNP) in nine young, healthy adults. Changes in microvascular flow were verified against changes in middle cerebral artery velocity (MCAv) measured by transcranial Doppler ultrasound. Results: LBNP significantly decreased arterial blood pressure ( Conclusion: Transient hypotension caused significantly larger blood flow and oxygenation changes in the extracerebral tissue compared to the brain. We demonstrate the importance of accounting for extracerebral signal contamination within optical measures of cerebral hemodynamics during physiological paradigms designed to test cerebral autoregulation.
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