Evidence map›Paper›PMID 37284046›Full record

ArticleEuropean urology open science2023

Germline

Rafael Grochot, Suzanne Carreira, Susana Miranda, Ines Figueiredo, Claudia Bertan, Jan Rekowski, Wei Yuan, Ana Ferreira, Ruth Riisnaes, Antje Neeb and 9 more

Open access · goldAbstract read
In one paragraph

Article in European urology open science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 3 institutions in 1 country.

Rafael GrochotThe Institute of Cancer Research (ICR), London, UK.
Suzanne CarreiraThe Institute of Cancer Research (ICR), London, UK.
Susana MirandaThe Institute of Cancer Research (ICR), London, UK.
Ines FigueiredoThe Institute of Cancer Research (ICR), London, UK.
Claudia BertanThe Institute of Cancer Research (ICR), London, UK.
Jan RekowskiThe Institute of Cancer Research (ICR), London, UK.
Wei YuanThe Institute of Cancer Research (ICR), London, UK.
Ana FerreiraThe Institute of Cancer Research (ICR), London, UK.
Ruth RiisnaesThe Institute of Cancer Research (ICR), London, UK.
Antje NeebThe Institute of Cancer Research (ICR), London, UK.
Bora GurelThe Institute of Cancer Research (ICR), London, UK.
Maria de Los Dolores Fenor de la MazaThe Institute of Cancer Research (ICR), London, UK.
Christina GuoThe Institute of Cancer Research (ICR), London, UK.
Juliet CarmichaelThe Institute of Cancer Research (ICR), London, UK.
Daniel WestabyThe Institute of Cancer Research (ICR), London, UK.
Joaquin MateoVall Hebron Institute of Oncology, Barcelona, Spain.
Adam SharpThe Institute of Cancer Research (ICR), London, UK.
Terri P McVeighRoyal Marsden NHS Foundation Trust (RMH), London, UK.
Johann De BonoThe Institute of Cancer Research (ICR), London, UK.
Institute of Cancer Research · GBRoyal Marsden NHS Foundation Trust · GBVall d'Hebron Institute of Oncology

Funding

Medical Research Council MR/W018217/1
6 · The paper itself

Abstract

Background: Germline mutations in the ataxia telangiectasia mutated ( Objective: To report on the clinical characteristics including family history and clinical outcomes of a cohort of patients with advanced metastatic castration-resistant PC (CRPC) who were found to have germline Design setting and participants: We acquired germline Outcome measurements and statistical analysis: Outcome endpoints were based on overall survival (OS) and time from diagnosis to CRPC. Data were analysed using R version 3.6.2 (R Foundation for Statistical Computing, Vienna, Austria). Results and limitations: Overall, seven patients ( Conclusions: Germline Patient summary: In this report, we studied the clinical and pathological features of advanced prostate cancers associated with germline mutations in the

Indexed as

ATMATR inhibitionDNA damage responsePARP inhibitionProstate cancerSynthetic lethality

Identifiers

PMID37284046
PMCPMC10240520
OpenAlexW4367675151

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.