Evidence map›Paper›PMID 37284016›Full record

ArticleFrontiers in aging neuroscience2023

Investigation of brain iron levels in Chinese patients with Alzheimer's disease.

Chuanbin Huang, Jing Li, Chang Liu, Yong Zhang, Qiqiang Tang, Xinyi Lv, Mengyue Ruan, Kexue Deng

Open access · goldAbstract read
In one paragraph

Article in Frontiers in aging neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 3 pooled it
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 3 syntheses or guidelines pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. [Research progress on quantitative magnetic susceptibility imaging reconstruction method based on improved U-network model].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2025
    Review
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Chuanbin Huang *The First Affiliated Hospital of University of Science and Technology of China Anhui Provincial Hospital, Hefei, China.
Jing Li *Fuyang Hospital of Anhui Medical University, Fuyang, Anhui, China.
Chang LiuThe First Affiliated Hospital of University of Science and Technology of China Anhui Provincial Hospital, Hefei, China.
Yong ZhangGE HealthCare, Shanghai, China.
Qiqiang TangThe First Affiliated Hospital of University of Science and Technology of China Anhui Provincial Hospital, Hefei, China.
Xinyi LvThe First Affiliated Hospital of University of Science and Technology of China Anhui Provincial Hospital, Hefei, China.
Mengyue RuanThe First Affiliated Hospital of University of Science and Technology of China Anhui Provincial Hospital, Hefei, China.
Kexue DengThe First Affiliated Hospital of University of Science and Technology of China Anhui Provincial Hospital, Hefei, China.
Anhui Provincial Hospital · CNUniversity of Science and Technology of China · CNFuyang Second People's Hospital · CNUnited Imaging Healthcare (China) · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: We aimed (i) to explore the diagnostic value of deep gray matter magnetic susceptibility in Alzheimer's disease (AD) in China and (ii) to analyze its correlation with neuropsychiatric scales. Moreover, we conducted subgroup analysis based on the presence of the Methods: From the prospective studies of the China Aging and Neurodegenerative Initiative (CANDI), a total of 93 subjects who could undergo complete quantitative magnetic susceptibility imaging and Results: In primary analysis, the magnetic susceptibility values of the bilateral caudate nucleus and right putamen in the AD group and of the right caudate nucleus in the MCI group were significantly higher than those in the HCs group ( Discussion: Exploration of the correlation between deep gray matter iron levels and AD may provide insight into the pathogenesis of AD and facilitate early diagnosis in elderly Chinese. Further subgroup analysis based on the presence of the

Indexed as

Alzheimer’s diseaseAPOEmild cognitive impairmentMRIquantitative susceptibility mapping

Identifiers

PMID37284016
PMCPMC10239950
OpenAlexW4377293764

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.