ArticleThe Lancet regional health. Western Pacific2023
Incident cardiovascular-kidney disease, diabetic ketoacidosis, hypoglycaemia and mortality in adult-onset type 1 diabetes: a population-based retrospective cohort study in Hong Kong.
Article in The Lancet regional health. Western Pacific, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.
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11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 9 citations in OpenAlex.
- Association between type 1 diabetes mellitus and dental caries in children and adolescents: a meta-analysis and Mendelian randomization study.Frontiers in endocrinology · 2026Pooled it
- A systematic literature review on the burden of diabetic ketoacidosis in type 2 diabetes mellitus.Diabetes, obesity & metabolism · 2025Pooled it
- Life-threatening acute complications persist among individuals with type 1 diabetes in Japan: A nationwide registry-based cross-sectional study.Journal of diabetes investigation · 2026Article
- Trends in cardiovascular disease prevalence among adults with type 1 diabetes in the USA: analysis of commercial claims data, 2017-2021.BMJ open diabetes research & care · 2025Article
- Heterogeneity in the development of diabetes-related complications: narrative review of the roles of ancestry and geographical determinants.Diabetologia · 2025Review
- Epidemiological trend in diabetic kidney disease (DKD) burden in China from 1990 to 2021, and projections for 2041: an analysis of the global burden of disease study 2021.BMC public health · 2025Article
- Development of a Chinese-Specific Clinical Model to Predict Maturity-Onset Diabetes of the Young.Diabetes/metabolism research and reviews · 2025Article
- Young-onset type 2 diabetes-Epidemiology, pathophysiology, and management.Journal of diabetes investigation · 2025Review
- Increased cardiovascular risk in people with LADA in comparison to type 1 diabetes and type 2 diabetes: Findings from the DPV registry in Germany and Austria.Diabetes, obesity & metabolism · 2025Article
- Adiposity in Chinese people with type 1 diabetes.World journal of diabetes · 2024Article
- Age at onset of type 1 diabetes between puberty and 30 years old is associated with increased diabetic nephropathy risk.Scientific reports · 2024Article
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Type 1 diabetes can occur at any age. The majority of literature on type 1 diabetes were reported in children whereas adult-onset type 1 diabetes is less well characterised. This study aims to compare the risk of diabetes-related complications and mortality in Chinese with adult-onset type 1 diabetes versus those with youth-onset type 1 diabetes and adult-onset type 2 diabetes. Methods: Between 2000 and 2018, 2738 people with type 1 and 499,288 with type 2 diabetes underwent metabolic and complication assessment in Hong Kong Hospital Authority. They were followed for incident diabetic ketoacidosis (DKA), severe hypoglycaemia, end-stage kidney disease (ESKD), cardiovascular disease (CVD) and all-cause mortality until 2019. Findings: In multivariable Cox regression adjusted for sex, diabetes duration and calendar year, people with type 1 diabetes diagnosed aged ≥40 years had a lower hazard of DKA (hazard ratio HR [95% CI] 0.47 [0.32-0.70]) but higher hazards of severe hypoglycaemia (HR 1.37 [1.13-1.67]), ESKD (HR 4.62 [2.90-7.37]), CVD (HR 11.44 [6.92-18.91]) and mortality (HR 16.22 [11.43-23.02]) versus those diagnosed aged <20 years. Compared with peers with type 2 diabetes presenting at comparable age, people with type 1 diabetes diagnosed aged ≥40 years had higher age-, sex- and diabetes duration-adjusted hazards of DKA (HR 19.87 [13.95-28.31]), severe hypoglycaemia (HR 3.26 [2.81-3.80]), ESKD (HR 1.58 [1.20-2.09]) and mortality (HR 2.26 [1.96-2.60]), and a similar hazard of CVD (HR 1.11 [0.87-1.43]). These associations remained constant after adjustment for metabolic indices. Interpretation: People with type 1 diabetes diagnosed in late adulthood had elevated risks of a broad range of complications and mortality compared with people with youth-onset type 1 diabetes and people with type 2 diabetes presenting at same age bands. Funding: This study did not receive any specific funding.
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