Evidence map›Paper›PMID 37283810›Full record

ArticleiScience2023

A pref-1-controlled non-inflammatory mechanism of insulin resistance.

Yiheng Huang, Donghong Cui, Liujun Chen, Haibin Tong, Hong Wu, Grace K Muller, Yadan Qi, Shuxia Wang, Jinjie Xu, Xiang Gao and 11 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 13 institutions in 3 countries.

Yiheng HuangCollege of Pharmacy, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada.
Donghong CuiShanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Liujun ChenCollege of Pharmacy, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada.
Haibin TongCollege of Life and Environment Sciences, Wenzhou University, Wenzhou, Zhejiang, China.
Hong WuInstitute of Cardiovascular Disease, Henan University of Chinese Medicine, Zhengzhou, Henan, China.
Grace K MullerDepartment of Cell and Molecular Physiology, Loyola University, Chicago, IL, USA.
Yadan QiCollege of Pharmacy, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada.
Shuxia WangDepartment of Cardiology, The General Hospital of Chinese PLA, Beijing, China.
Jinjie XuBeijing Anding Hospital, Capital Medical University, Beijing, China.
Xiang GaoCollege of Life Sciences, Qingdao University, Qingdao, Shandong, China.
Kathleen E FifieldDivision of Biomedical Sciences, Faculty of Medicine, Memorial University of Newfoundland, St. John's, NL, Canada.
Lingyan WangDivision of Biomedical Sciences, Faculty of Medicine, Memorial University of Newfoundland, St. John's, NL, Canada.
Zhengyuan XiaGuangdong Medical University, Zhanjiang, China.
Jacqueline L VanderluitDivision of Biomedical Sciences, Faculty of Medicine, Memorial University of Newfoundland, St. John's, NL, Canada.
Suixin LiuDivision of Cardiac Rehabilitation, Department of Physical Medicine & Rehabilitation, Xiangya Hospital of Central South University, Changsha, Hunan, China.
Lin LengDepartment of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA.
Guang SunDivision of Biomedical Sciences, Faculty of Medicine, Memorial University of Newfoundland, St. John's, NL, Canada.
John McGuireDepartment of Medical Biophysics, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada.
Lawrence H YoungDepartment of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA.
Richard BucalaDepartment of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA.
Dake QiCollege of Pharmacy, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada.
Memorial University of Newfoundland · CAUniversity of Manitoba · CAYale University · USBeijing Anding Hospital · CNCentral South University · CNChinese PLA General Hospital · CNFirst Affiliated Hospital of Henan University · CNGuangdong Medical College · CNLoyola University Chicago · USQingdao University · CNShanghai Jiao Tong University · CNWenzhou University · CNWestern University · CA

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Defining the Pathogenic Contribution of High Genotypic MIF ExpressionR01AR078334 · NIAMS · YALE UNIVERSITY · PI BUCALA, RICHARD J · 2021 to 2025
$1.8M
NCATS NIH HHS UL1 TR001863NIAMS NIH HHS R01 AR078334
6 · The paper itself

Abstract

While insulin resistance (IR) is associated with inflammation in white adipose tissue, we report a non-inflammatory adipose mechanism of high fat-induced IR mediated by loss of Pref-1. Pref-1, released from adipose Pref-1+ cells with characteristics of M2 macrophages, endothelial cells or progenitors, inhibits MIF release from both Pref-1+ cells and adipocytes by binding with integrin β1 and inhibiting the mobilization of p115. High palmitic acid induces PAR2 expression in Pref-1+ cells, downregulating Pref-1 expression and release in an AMPK-dependent manner. The loss of Pref-1 increases adipose MIF secretion contributing to non-inflammatory IR in obesity. Treatment with Pref-1 blunts the increase in circulating plasma MIF levels and subsequent IR induced by a high palmitic acid diet. Thus, high levels of fatty acids suppress Pref-1 expression and secretion, through increased activation of PAR2, resulting in an increase in MIF secretion and a non-inflammatory adipose mechanism of IR.

Indexed as

Cell biologyImmunologyMolecular biologyTranscriptomics

Identifiers

PMID37283810
PMCPMC10239698
OpenAlexW4377139833

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.